Distinct cell shapes determine accurate chemotaxis.
Distinct cell shapes determine accurate chemotaxis.
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不同的细胞形状决定了准确的趋化性。
DOI：
10.1038/srep02606
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发表时间：
2013
影响因子：
4.6
通讯作者：
Endres, Robert G.
中科院分区：
文献类型：
--
作者：
Tweedy, Luke;Meier, Boern;Stephan, Juergen;Heinrich, Doris;Endres, Robert G.
生物体的行为往往反映了其应对环境的策略。由于生理限制，高等生物的这种行为通常可以简化为几种定型的运动模式，但在变形虫细胞中找到这种模式更为困难，因为它们缺乏这些限制。在这里，我们研究细胞的形状和运动在饥饿的Dictyosteobacteriumamoeobacterium在微流控室中向化学引诱物迁移。我们表明，在整个人口的变形虫形状的令人难以置信的变化可以减少到几个模式的变化。有趣的是，细胞根据所施加的化学梯度使用不同的模式，特定的细胞形状与浅的、难以感知的梯度相关。建模和药物治疗表明，这些行为与物理极限的准确感知有着内在的联系。由于在不同的细胞类型中观察到类似的行为，我们认为细胞的形状和行为是保守的特征。
The behaviour of an organism often reflects a strategy for coping with its environment. Such behaviour in higher organisms can often be reduced to a few stereotyped modes of movement due to physiological limitations, but finding such modes in amoeboid cells is more difficult as they lack these constraints. Here, we examine cell shape and movement in starved Dictyostelium amoebae during migration toward a chemoattractant in a microfluidic chamber. We show that the incredible variety in amoeboid shape across a population can be reduced to a few modes of variation. Interestingly, cells use distinct modes depending on the applied chemical gradient, with specific cell shapes associated with shallow, difficult-to-sense gradients. Modelling and drug treatment reveals that these behaviours are intrinsically linked with accurate sensing at the physical limit. Since similar behaviours are observed in a diverse range of cell types, we propose that cell shape and behaviour are conserved traits.
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影响因子：
3.7
作者：
Smith ZJ;Chu K;Espenson AR;Rahimzadeh M;Gryshuk A;Molinaro M;Dwyre DM;Lane S;Matthews D;Wachsmann-Hogiu S
通讯作者：
Wachsmann-Hogiu S
影响因子：
21.3
作者：
Andrew, Natalie;Insall, Robert H.
通讯作者：
Insall, Robert H.
DOI：
10.1073/pnas.1014853108
发表时间：
2011-07-12
影响因子：
11.1
作者：
Meier, Born;Zielinski, Alejandro;Heinrich, Doris
通讯作者：
Heinrich, Doris
影响因子：
64.8
作者：
Keren, Kinneret;Pincus, Zachary;Theriot, Julie A.
通讯作者：
Theriot, Julie A.
影响因子：
2.5
作者：
Skoge, Monica;Adler, Micha;Rappel, Wouter-Jan
通讯作者：
Rappel, Wouter-Jan