Cell-phone-based platform for biomedical device development and education applications.
Cell-phone-based platform for biomedical device development and education applications.
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DOI：
10.1371/journal.pone.0017150
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发表时间：
2011-03-02
期刊：
影响因子：
3.7
通讯作者：
Wachsmann-Hogiu S
中科院分区：
文献类型：
--
作者：
Smith ZJ;Chu K;Espenson AR;Rahimzadeh M;Gryshuk A;Molinaro M;Dwyre DM;Lane S;Matthews D;Wachsmann-Hogiu S
在本文中，我们报告了两种附件的开发，这两种附件可以将手机的集成镜头和图像传感器转换为350×显微镜和可见光光谱仪。该显微镜能够传输和偏振显微镜模式，并显示有1.5微米的分辨率和一个可用的视场150×150没有图像处理，大约350×350时，后处理应用。该光谱仪的带宽为300纳米，极限光谱分辨率接近5纳米。我们展示了这些设备在医学相关问题上的应用。在显微镜的情况下，我们对染色和未染色的血液涂片进行成像，显示出获得与商业显微镜平台相似质量的图像的能力，从而允许临床病理诊断。利用光谱仪，我们演示了通过漫射组织采集白光透射光谱以及荧光光谱的采集。我们还设想这些设备在教育领域具有直接的相关性。
In this paper we report the development of two attachments to a commercial cell phone that transform the phone's integrated lens and image sensor into a 350× microscope and visible-light spectrometer. The microscope is capable of transmission and polarized microscopy modes and is shown to have 1.5 micron resolution and a usable field-of-view of 150×150 with no image processing, and approximately 350×350 when post-processing is applied. The spectrometer has a 300 nm bandwidth with a limiting spectral resolution of close to 5 nm. We show applications of the devices to medically relevant problems. In the case of the microscope, we image both stained and unstained blood-smears showing the ability to acquire images of similar quality to commercial microscope platforms, thus allowing diagnosis of clinical pathologies. With the spectrometer we demonstrate acquisition of a white-light transmission spectrum through diffuse tissue as well as the acquisition of a fluorescence spectrum. We also envision the devices to have immediate relevance in the educational field.
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