Frequency of antibiotic resistance in Helicobacter pylori strains isolated from the northern population of Iran.
Frequency of antibiotic resistance in Helicobacter pylori strains isolated from the northern population of Iran.
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DOI：
10.1007/s12275-011-1170-6
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发表时间：
2011-12
影响因子：
3
通讯作者：
Merrell, D. Scott
中科院分区：
文献类型：
--
作者：
Abadi, Amin Talebi Bezmin;Taghvaei, Tarang;Mobarez, Ashraf Mohabbati;Carpenter, Beth M.;Merrell, D. Scott
本研究的目的是评估近期临床幽门螺杆菌分离株对伊朗最常用抗生素的原发性耐药率。本研究纳入了2009年1月至7月期间出现胃病的210例患者。进行内镜检查，并从每个病人的活检标本收集随后的细菌培养H。幽门。然后将来自每个患者的单菌落分离株用于抗菌药物敏感性测试。采用纸片扩散法测定药敏曲线。197例为H. pylori阳性（93.8%）。对四环素、阿莫西林、环丙沙星、甲硝唑、克拉霉素和呋喃唑酮的耐药率分别为37.1%、23.9%、34.5%、65.5%、45.2%和61.4%。阿莫西林耐药率与疾病状态显著相关（P <0.05）。此外，一些双重，三重，四重和五重组合的抗生素耐药性被发现与疾病状态。本研究评估了H. pylori对伊朗最常用的处方抗生素的耐药性，表明耐药率普遍高于以前的报道。这一数据增加了越来越多的证据表明，在H。幽门螺杆菌分离株，这可能是负责抗H.幽门螺杆菌治疗在当地和全球水平。因此，有必要继续监测耐药模式，特别是在地方一级，并将这些信息纳入H。幽门感染。
The purpose of this study was to evaluate the primary resistance rates of recent clinical Helicobacter pylori isolates to the most commonly used antibiotics in Iran. 210 patients presenting with gastric maladies between January and July of 2009 were enrolled in this study. Endoscopy was performed, and biopsy specimens were collected from each patient for subsequent bacterial culture of H. pylori. Single colony isolates from each patient were then used for antimicrobial susceptibility testing. The disk diffusion method was used to determine susceptibility patterns. 197 of the patients were H. pylori positive (93.8%). The rates of resistance to tetracycline, amoxicillin, ciprofloxacin, metronidazole, clarithromycin, and furizoladone were 37.1%, 23.9%, 34.5%, 65.5%, 45.2%, and 61.4%, respectively. A significant association between amoxicillin resistance and disease state (P <0.05) was identified. Furthermore, some double, triple, quadruple, and quintuple combinations of antibiotic resistance were found to be associated with disease state. This study evaluated the prevalence of H. pylori resistance to the most commonly prescribed antibiotics used in Iran and showed that resistance rates were generally higher than previously reported. This data adds to the growing body of evidence that suggests there is increasing antibiotic resistance among H. pylori isolates, which likely is responsible for the decreasing efficacy of anti-H. pylori therapy at the local and global level. Hence, there is a need for continued monitoring of resistance patterns, especially at the local level, and for incorporation of that information into treatment regimens for H. pylori infections.
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影响因子：
4.4
作者：
Abadi, Amin Talebi Bezmin;Mobarez, Ashraf M.;Wolfram, Lutz
通讯作者：
Wolfram, Lutz
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3
作者：
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通讯作者：
Koumanova, R