Striatal D(2)/D(3) receptor availability is inversely correlated with cannabis consumption in chronic marijuana users.
Striatal D(2)/D(3) receptor availability is inversely correlated with cannabis consumption in chronic marijuana users.
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DOI：
10.1016/j.drugalcdep.2012.07.016
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发表时间：
2013-02-01
影响因子：
4.2
通讯作者：
Yoder, Karmen K.
中科院分区：
文献类型：
--
作者：
Albrecht, Daniel S.;Skosnik, Patrick D.;Vollmer, Jennifer M.;Brumbaugh, Margaret S.;Perry, Kevin M.;Mock, Bruce H.;Zheng, Qi-Huang;Federici, Lauren A.;Patton, Elizabeth A.;Herring, Christine M.;Yoder, Karmen K.
虽然美国人滥用/依赖大麻的发生率正在上升，但大麻成瘾的神经生物学尚未得到很好的理解。影像学研究表明，在几个物质依赖人群中，纹状体D2/D3受体的可用性不足。然而，这还没有在目前使用大麻的慢性使用者中进行研究。本研究的目的是比较目前使用的慢性大麻使用者和健康对照者之间的纹状体D2/D3受体的可用性。18名18-34岁的右利手男性进行了研究。10名受试者为慢性大麻使用者; 8名为人口统计学匹配的对照组。受试者接受[11 C]雷氯必利（RAC）PET扫描。在逐体素的基础上计算纹状体RAC结合潜力（BPND）。扫描前，从大麻使用者中获取尿液样本，用于定量尿液Δ-9-四氢大麻酚（THC）和THC代谢物（11-去甲-Δ-9-THC-9-羧酸; THC-COOH和11-羟基-THC;OH-THC）。大麻使用者和对照组之间的D2/D3受体可用性没有差异。体素分析显示，RAC BPND值与大麻代谢物的尿液水平和最近大麻消费的自我报告呈负相关。在这个样本中，目前使用大麻与纹状体D2/D3受体可用性的缺陷无关。慢性大麻使用与纹状体RAC BPND之间存在反比关系。需要进一步的研究来确定长期使用大麻对多巴胺系统的神经化学后果。
Although the incidence of cannabis abuse/dependence in Americans is rising, the neurobiology of cannabis addiction is not well understood. Imaging studies have demonstrated deficits in striatal D2/D3 receptor availability in several substance-dependent populations. However, this has not been studied in currently-using chronic cannabis users. The purpose of this study was to compare striatal D2/D3 receptor availability between currently-using chronic cannabis users and healthy controls. Eighteen right-handed males age 18–34 were studied. Ten subjects were chronic cannabis users; eight were demographically matched controls. Subjects underwent a [11C] raclopride (RAC) PET scan. Striatal RAC binding potential (BPND) was calculated on a voxel-wise basis. Prior to scanning, urine samples were obtained from cannabis users for quantification of urine Δ-9-tetrahydrocannabinol (THC) and THC metabolites (11-nor-Δ-9-THC-9-carboxylic acid; THC-COOH and 11-hydroxy-THC;OH-THC). There were no differences in D2/D3 receptor availability between cannabis users and controls. Voxel-wise analyses revealed that RAC BPND values were negatively associated with both urine levels of cannabis metabolites and self-report of recent cannabis consumption. In this sample, current cannabis use was not associated with deficits in striatal D2/D3 receptor availability. There was an inverse relationship between chronic cannabis use and striatal RAC BPND. Additional studies are needed to identify the neurochemical consequences of chronic cannabis use on the dopamine system.
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影响因子：
3.7
作者：
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通讯作者：
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