Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation.
Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation.
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DOI：
10.1038/s41467-018-05911-0
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发表时间：
2018-09-04
影响因子：
16.6
通讯作者：
Horsley V
中科院分区：
文献类型：
--
作者：
Zwick RK;Rudolph MC;Shook BA;Holtrup B;Roth E;Lei V;Van Keymeulen A;Seewaldt V;Kwei S;Wysolmerski J;Rodeheffer MS;Horsley V
脂肪细胞在大小和行为上发生显著变化，以支持不同的组织功能，但控制这些变化的机制还不清楚。乳腺相关的白色脂肪组织（mgWAT）在哺乳期间支持乳脂产生，并在随后的产奶上皮细胞退化期间扩张，提供了脂肪生长的最显著的生理学实例之一。我们研究了小鼠乳腺（MG）脂肪细胞和脂质动力学的细胞机制和功能意义。使用体内脂肪细胞前体分析和成熟脂肪细胞的遗传追踪，我们发现成熟脂肪细胞肥大是退化过程中mgWAT扩张的主要机制。脂质追踪和脂质组学表明脂肪细胞充满上皮来源的乳脂。此外，消融的mgWAT在退化过程中揭示了一个重要的作用，脂肪细胞的牛奶运输，并适当的重组，乳腺上皮。这项工作推进了我们对MG重塑和脂肪细胞组织特异性作用的理解。在乳腺退化过程中，该器官经历广泛的重塑。在这里，作者探讨了乳腺脂肪组织（mgWAT）在这一过程中的作用，并证明脂肪细胞肥大和脂质运输是mgWAT扩张和上皮退化的基础。
Adipocytes undergo pronounced changes in size and behavior to support diverse tissue functions, but the mechanisms that control these changes are not well understood. Mammary gland-associated white adipose tissue (mgWAT) regresses in support of milk fat production during lactation and expands during the subsequent involution of milk-producing epithelial cells, providing one of the most marked physiological examples of adipose growth. We examined cellular mechanisms and functional implications of adipocyte and lipid dynamics in the mouse mammary gland (MG). Using in vivo analysis of adipocyte precursors and genetic tracing of mature adipocytes, we find mature adipocyte hypertrophy to be a primary mechanism of mgWAT expansion during involution. Lipid tracking and lipidomics demonstrate that adipocytes fill with epithelial-derived milk lipid. Furthermore, ablation of mgWAT during involution reveals an essential role for adipocytes in milk trafficking from, and proper restructuring of, the mammary epithelium. This work advances our understanding of MG remodeling and tissue-specific roles for adipocytes. During mammary gland involution, the organ undergoes extensive remodeling. Here, the authors explore the role of mammary gland adipose tissue (mgWAT) in this process and demonstrate that adipocyte hypertrophy and lipid trafficking underlie mgWAT expansion and epithelial regression.
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影响因子：
2.5
作者：
Hovey, Russell C.;Aimo, Lucila
通讯作者：
Aimo, Lucila
影响因子：
29
作者：
Jeffery E;Wing A;Holtrup B;Sebo Z;Kaplan JL;Saavedra-Peña R;Church CD;Colman L;Berry R;Rodeheffer MS
通讯作者：
Rodeheffer MS
影响因子：
2.5
作者：
Couldrey, C;Moitra, J;Green, J
通讯作者：
Green, J
DOI：
10.1073/pnas.0805621105
发表时间：
2008-09-02
影响因子：
11.1
作者：
Birsoy, Kivanc;Soukas, Alexander;Friedman, Jeffrey M.
通讯作者：
Friedman, Jeffrey M.
影响因子：
64.5
作者：
Festa E;Fretz J;Berry R;Schmidt B;Rodeheffer M;Horowitz M;Horsley V
通讯作者：
Horsley V