Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study.
Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study.
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DOI：
10.1038/s41440-019-0335-2
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Hozawa A
中科院分区：
文献类型：
--
作者：
Kogure M;Hirata T;Nakaya N;Tsuchiya N;Nakamura T;Narita A;Miyagawa K;Koshimizu H;Obara T;Metoki H;Uruno A;Kikuya M;Sugawara J;Kuriyama S;Tsuji I;Kure S;Hozawa A
先前的研究已经报道了尿钠钾（Na/K）比值与高血压之间的正相关性，并且与单次测量相比，多次测量偶然尿Na/K比值与24小时尿Na/K比值的相关性更强。尿Na/K比值的多项测量可能与高血压更密切相关。我们的目的是确定与单一测量相比，多次测量偶然尿钠/钾比值与家庭高血压之间的相关性。在日本宫城县进行了一项基于人群的横断面研究。受试者年龄超过20岁，参加了东北医疗Megabank项目队列研究。我们针对3273名连续10天借用家庭血压（HBP）监测仪和尿Na/K比值监测仪的受试者。采用多元Logistic回归模型分析尿Na/K比值与家庭高血压（HBP ≥ 135/85 mmHg或正在接受高血压治疗）之间的关系。为了比较多项测量与单项测量对家庭高血压的预测，我们计算了受试者工作特征曲线下面积（AUROC）。与家庭高血压密切相关的尿Na/K比值的多次测量优于1或2天的测量（6天内尿Na/K比值每单位增加的家庭高血压校正比值比：1.13-1.15）。家庭高血压患者尿Na/K比值测定的AUROC在5天后稳定（AUROC = 0.779）。总之，多次测量尿钠/钾比值与家庭高血压密切相关。这一发现表明，尿钠/钾比值的多项测量是有用的评估家庭高血压。
Previous studies have reported a positive association between the urinary sodium-to-potassium (Na/K) ratio and hypertension, and multiple measurements of the casual urinary Na/K ratio are more strongly correlated with the 24-h urinary Na/K ratio than a single measurement. Multiple measurements of the urinary Na/K ratio might be more strongly associated with hypertension. We aimed to determine the association between multiple measurements of the casual urinary Na/K ratio and home hypertension compared with a single measurement. A population-based cross-sectional study was performed in Miyagi Prefecture, Japan. Subjects were over 20 years old and participated in the Tohoku Medical Megabank Project Cohort Study. We targeted 3273 subjects who borrowed home blood pressure (HBP) monitors and urinary Na/K ratio monitors for 10 consecutive days. The association between the urinary Na/K ratio and home hypertension (HBP ≥ 135/85 mmHg or under treatment for hypertension) was examined using multiple logistic regression models. To compare the prediction of home hypertension using multiple measurements with that using a single measurement, we calculated the area under the receiver operating characteristic curve (AUROC). Multiple measurements of the urinary Na/K ratio strongly related to home hypertension were better than 1 or 2 days of measurement (adjusted odds ratio of home hypertension per unit increase in urinary Na/K ratio over 6 days: 1.13–1.15). The AUROC of the urinary Na/K ratio measurement for home hypertension was stable after 5 days (AUROC = 0.779). In conclusion, multiple measurements of the urinary Na/K ratio are strongly related to home hypertension. This finding suggests that multiple measurements of the urinary Na/K ratio are useful for evaluating home hypertension.
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影响因子：
7.7
作者：
Iwahori T;Miura K;Ueshima H;Chan Q;Dyer AR;Elliott P;Stamler J;INTERSALT Research Group
通讯作者：
INTERSALT Research Group
影响因子：
158.5
作者：
Mente, Andrew;O'Donnell, Martin J.;Yusuf, Salim
通讯作者：
Yusuf, Salim
影响因子：
4.9
作者：
Ohkubo, T;Asayama, K;Imai, Y
通讯作者：
Imai, Y
影响因子：
120.7
作者：
Forouzanfar, Mohammad H.;Liu, Patrick;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
DOI：
10.1136/bmj.f1326
发表时间：
2013-04-03
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Aburto NJ;Ziolkovska A;Hooper L;Elliott P;Cappuccio FP;Meerpohl JJ
通讯作者：
Meerpohl JJ