The role of Sfrp and DKK proteins in cardiomyocyte development.
The role of Sfrp and DKK proteins in cardiomyocyte development.
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DOI：
10.14814/phy2.14678
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发表时间：
2021-03
影响因子：
2.5
通讯作者：
Gomez JA
中科院分区：
文献类型：
--
作者：
Hsueh YC;Hodgkinson CP;Gomez JA
本文就Wnt蛋白在心肌发生中的作用作一综述。更具体地说，我们专注于如何从前体细胞的心肌细胞的发展涉及Wnt经典β-catenin信号通路和Wnt非经典信号通路之间的复杂相互作用，涉及PCP和JNK。我们还描述了最近的文献表明，内源性Wnt抑制剂，如Sfrp和DKK蛋白在调节心肌细胞分化中发挥重要作用。Srfp 2通过抑制Wnt 3a介导心肌细胞分化。Wnt 3a是激活B-连环蛋白并抑制心脏特化的典型Wnt。相比之下，Wnt 11是一种非经典Wnt，抑制B-连环蛋白并促进向心肌细胞的分化。Sfrp 2的加入扰乱了这种平衡，因为它结合并隔离Wnt 3a，但不隔离Wnt 11;从而使Wnt 11自由结合Fzd 5并激活非经典途径，导致心脏分化。
In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β‐catenin signaling pathways and Wnt noncanonical signaling pathways involving PCP and JNK. We also describe recent literature which suggests that endogenous Wnt inhibitors such as the Sfrp and DKK proteins play important roles in regulating the cardiomyocyte differentiation. Srfp2 mediates cardiomyocyte differentiation by inhibiting Wnt3a. Wnt3a is a canonical Wnt that activates b‐catenin and inhibits cardiac specification. In contrast, Wnt11 is a noncanonical Wnt, inhibits b‐catenin and promotes differentiation into cardiomyocytes. The addition of Sfrp2 upsets this balance as it binds, and sequesters, Wnt3a but not Wnt11; thereby leaving Wnt11 free to bind to Fzd5 and activate the noncanonical pathway resulting in cardiac differentiation.
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