Beyond dueling: roles of the type VI secretion system in microbiome modulation, pathogenesis and stress resistance.

Beyond dueling: roles of the type VI secretion system in microbiome modulation, pathogenesis and stress resistance.
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超越决斗:VI 型分泌系统在微生物组调节、发病机制和应激抵抗中的作用

DOI:
10.1007/s44154-021-00008-z
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发表时间:
2021-11-03
期刊:
Stress biology
影响因子:
--
通讯作者:
Shen, Xihui
Shen, Xihui
中科院分区:
其他
文献类型:
--
作者:
Lin, Jinshui;Xu, Lei;Yang, Jianshe;Wang, Zhuo;Shen, Xihui

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细菌栖息在多样化和动态的环境中,营养物质可能有限,有毒化学物质可能普遍存在。为了适应这些应激条件,细菌进化出专门的蛋白质分泌系统,如VI型分泌系统(T6SS),以促进其生存。作为分子注射器,T6SS将各种效应物排出到邻近的细菌细胞、真核细胞或细胞外环境中。这些效应子提高了细菌细胞的竞争适应性和环境适应性。虽然最初被认为是抗菌武器,但最近的研究表明,T6SS具有超越物种间竞争的功能。在这里,我们总结了最近关于T6SSs在微生物组调节,发病机制和应激抗性中的作用的研究。
Bacteria inhabit diverse and dynamic environments, where nutrients may be limited and toxic chemicals can be prevalent. To adapt to these stressful conditions, bacteria have evolved specialized protein secretion systems, such as the type VI secretion system (T6SS) to facilitate their survival. As a molecular syringe, the T6SS expels various effectors into neighboring bacterial cells, eukaryotic cells, or the extracellular environment. These effectors improve the competitive fitness and environmental adaption of bacterial cells. Although primarily recognized as antibacterial weapons, recent studies have demonstrated that T6SSs have functions beyond interspecies competition. Here, we summarize recent research on the role of T6SSs in microbiome modulation, pathogenesis, and stress resistance.
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