Shining a spotlight on m6A and the vital role of RNA modification in endometrial cancer: a review.
Shining a spotlight on m6A and the vital role of RNA modification in endometrial cancer: a review.
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DOI：
10.3389/fgene.2023.1247309
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发表时间：
2023
影响因子：
3.7
通讯作者：
Huang, Yiping
中科院分区：
文献类型：
--
作者：
Jin, Zujian;Sheng, Jingjing;Hu, Yingying;Zhang, Yu;Wang, Xiaoxia;Huang, Yiping
RNA修饰主要是动态可逆的转录后修饰，其中m6A在真核生物mRNA中最普遍。越来越多的研究表明，RNA修饰可以微调基因表达，调节RNA代谢稳态，进而影响肿瘤细胞的自我更新、增殖、凋亡、迁移和侵袭。子宫内膜癌是发达国家最常见的妇科肿瘤。虽然它可以在发病早期诊断，预后较好，但有些病例可能会发展并成为转移或复发，预后较差。幸运的是，免疫治疗和靶向治疗是治疗子宫内膜癌患者的有前途的方法。基因修饰也可能有助于这些治疗，尤其是最近开发的新靶向治疗基因和EC诊断生物标志物，尽管目前关于RNA修饰与EC之间关系的研究结果仍然非常有限，尤其是m6A。例如，RNA修饰影响EC进展的复杂机制是什么？以m6A修饰为例，针对RNA的甲基化和去甲基化的转换模式是什么，如何实现对特定RNA的选择性识别？了解它们如何科普作为体内和体外生物发育，疾病或肿瘤发生和发展以及其他过程的一部分的各种刺激是有价值的，RNA修饰提供了对遗传信息的独特见解。这些过程在体内和体外应对各种刺激、生物发育、疾病或肿瘤发展中的作用不言而喻，可能成为未来癌症的新方向。本文综述了RNA修饰，特别是m6A修饰的种类、特点和治疗方案，旨在寻找与RNA修饰相关的系统调控轴，为食管癌的治疗提供更好的解决方案。
RNA modifications are mostly dynamically reversible post-transcriptional modifications, of which m6A is the most prevalent in eukaryotic mRNAs. A growing number of studies indicate that RNA modification can finely tune gene expression and modulate RNA metabolic homeostasis, which in turn affects the self-renewal, proliferation, apoptosis, migration, and invasion of tumor cells. Endometrial carcinoma (EC) is the most common gynecologic tumor in developed countries. Although it can be diagnosed early in the onset and have a preferable prognosis, some cases might develop and become metastatic or recurrent, with a worse prognosis. Fortunately, immunotherapy and targeted therapy are promising methods of treating endometrial cancer patients. Gene modifications may also contribute to these treatments, as is especially the case with recent developments of new targeted therapeutic genes and diagnostic biomarkers for EC, even though current findings on the relationship between RNA modification and EC are still very limited, especially m6A. For example, what is the elaborate mechanism by which RNA modification affects EC progression? Taking m6A modification as an example, what is the conversion mode of methylation and demethylation for RNAs, and how to achieve selective recognition of specific RNA? Understanding how they cope with various stimuli as part of in vivo and in vitro biological development, disease or tumor occurrence and development, and other processes is valuable and RNA modifications provide a distinctive insight into genetic information. The roles of these processes in coping with various stimuli, biological development, disease, or tumor development in vivo and in vitro are self-evident and may become a new direction for cancer in the future. In this review, we summarize the category, characteristics, and therapeutic precis of RNA modification, m6A in particular, with the purpose of seeking the systematic regulation axis related to RNA modification to provide a better solution for the treatment of EC.
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影响因子：
14.9
作者：
Boccaletto P;Stefaniak F;Ray A;Cappannini A;Mukherjee S;Purta E;Kurkowska M;Shirvanizadeh N;Destefanis E;Groza P;Avşar G;Romitelli A;Pir P;Dassi E;Conticello SG;Aguilo F;Bujnicki JM
通讯作者：
Bujnicki JM
子宫内膜癌m6A甲基化模式及肿瘤微环境分析
影响因子：
3.5
作者：
Chen, Junfeng;Luo, Xiaomei;Zhang, Yongli
通讯作者：
Zhang, Yongli
RMDisease：影响 RNA 修饰的遗传变异数据库，对表观转录组发病机制具有影响。
影响因子：
14.9
作者：
Chen K;Song B;Tang Y;Wei Z;Xu Q;Su J;de Magalhães JP;Rigden DJ;Meng J
通讯作者：
Meng J
DOI：
10.1093/database/bau023
发表时间：
2014
期刊：
Database : the journal of biological databases and curation
影响因子：
--
作者：
Dai E;Yu X;Zhang Y;Meng F;Wang S;Liu X;Liu D;Wang J;Li X;Jiang W
通讯作者：
Jiang W
影响因子：
9.5
作者：
Bai, Weiyang;Yang, Wen;Liao, Mingzhi
通讯作者：
Liao, Mingzhi