EpimiR: a database of curated mutual regulation between miRNAs and epigenetic modifications.
EpimiR: a database of curated mutual regulation between miRNAs and epigenetic modifications.
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DOI：
10.1093/database/bau023
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Jiang W
中科院分区：
文献类型：
--
作者：
Dai E;Yu X;Zhang Y;Meng F;Wang S;Liu X;Liu D;Wang J;Li X;Jiang W
表观遗传修饰和微小RNA（microRNA，miRNA）作为两种重要的基因表达调控因子，在人类多种疾病中发挥着重要作用。近年来，许多研究表明表观遗传学和miRNA可以通过多种方式相互影响。本研究建立了EpimiR数据库，从300多篇文献中收集了19种表观遗传修饰（如DNA甲基化、组蛋白乙酰化、H3 K4 me 3、H3 S10 p）与7个物种（包括智人、小家鼠、褐家鼠、原鸡、Epstein-Barr病毒、家犬和拟南芥）617个miRNAs之间的1974条调控规律。这些调控可以分为两部分：miR 2 Epi（103个条目描述miRNA如何调控表观遗传修饰）和Epi 2 miR（1871个条目描述表观遗传修饰如何影响miRNA）。EpimiR的每个条目不仅包含验证实验的基本描述（方法、物种、参考文献等），还清楚地阐明了表观遗传学和miRNA之间的调控途径。作为对精选信息的补充，EpimiR扩展到收集与miRNA相关的预测表观遗传特征（如预测的转录起始位点，上游CpG岛），以指导用户未来的生物学实验。最后，EpimiR提供下载和提交页面。因此，EpimiR为表观遗传修饰与miRNA之间的相互调控提供了一个较为全面的信息库，将促进表观遗传学与miRNA调控机制的研究。数据库URL：http://bioinfo.hrbmu.edu.cn/EpimiR/。
As two kinds of important gene expression regulators, both epigenetic modification and microRNA (miRNA) can play significant roles in a wide range of human diseases. Recently, many studies have demonstrated that epigenetics and miRNA can affect each other in various ways. In this study, we established the EpimiR database, which collects 1974 regulations between 19 kinds of epigenetic modifications (such as DNA methylation, histone acetylation, H3K4me3, H3S10p) and 617 miRNAs across seven species (including Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Epstein–Barr virus, Canis familiaris and Arabidopsis thaliana) from >300 references in the literature. These regulations can be divided into two parts: miR2Epi (103 entries describing how miRNA regulates epigenetic modification) and Epi2miR (1871 entries describing how epigenetic modification affects miRNA). Each entry of EpimiR not only contains basic descriptions of the validated experiment (method, species, reference and so on) but also clearly illuminates the regulatory pathway between epigenetics and miRNA. As a supplement to the curated information, the EpimiR extends to gather predicted epigenetic features (such as predicted transcription start site, upstream CpG island) associated with miRNA for users to guide their future biological experiments. Finally, EpimiR offers download and submission pages. Thus, EpimiR provides a fairly comprehensive repository about the mutual regulation between epigenetic modifications and miRNAs, which will promote the research on the regulatory mechanism of epigenetics and miRNA. Database URL: http://bioinfo.hrbmu.edu.cn/EpimiR/.
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影响因子：
11.2
作者：
Scott, GK;Mattie, ND;Benz, CC
通讯作者：
Benz, CC
影响因子：
7
作者：
Vrba, Lukas;Garbe, James C.;Futscher, Bernard W.
通讯作者：
Futscher, Bernard W.
影响因子：
4.3
作者：
Saito, Yoshimasa;Jones, Peter A.
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Jones, Peter A.
影响因子：
14.9
作者：
Wheeler, David L.;Barrett, Tanya;Benson, Dennis A.;Bryant, Stephen H.;Canese, Kathi;Chetvernin, Vyacheslav;Church, Deanna M.;DiCuccio, Michael;Edgar, Ron;Federhen, Scott;Feolo, Michael;Geer, Lewis Y.;Helmberg, Wolfgang;Kapustin, Yuri;Khovayko, Oleg;Landsman, David;Lipman, David J.;Madden, Thomas L.;Maglott, Donna R.;Miller, Vadim;Ostell, James;Pruitt, Kim D.;Schuler, Gregory D.;Shumway, Martin;Sequeira, Edwin;Sherry, Steven T.;Sirotkin, Karl;Souvorov, Alexandre;Starchenko, Grigory;Tatusov, Roman L.;Tatusova, Tatiana A.;Wagner, Lukas;Yaschenko, Eugene
通讯作者：
Yaschenko, Eugene
影响因子：
14.9
作者：
Fujita PA;Rhead B;Zweig AS;Hinrichs AS;Karolchik D;Cline MS;Goldman M;Barber GP;Clawson H;Coelho A;Diekhans M;Dreszer TR;Giardine BM;Harte RA;Hillman-Jackson J;Hsu F;Kirkup V;Kuhn RM;Learned K;Li CH;Meyer LR;Pohl A;Raney BJ;Rosenbloom KR;Smith KE;Haussler D;Kent WJ
通讯作者：
Kent WJ