Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes.
Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes.
复制标题
DOI：
10.1002/acn3.51367
复制
发表时间：
2021-06
影响因子：
5.3
通讯作者：
Feldman EL
中科院分区：
文献类型：
--
作者：
Rumora AE;Guo K;Alakwaa FM;Andersen ST;Reynolds EL;Jørgensen ME;Witte DR;Tankisi H;Charles M;Savelieff MG;Callaghan BC;Jensen TS;Feldman EL
The global rise in type 2 diabetes is associated with a concomitant increase in diabetic complications. Diabetic polyneuropathy is the most frequent type 2 diabetes complication and is associated with poor outcomes. The metabolic syndrome has emerged as a major risk factor for diabetic polyneuropathy; however, the metabolites associated with the metabolic syndrome that correlate with diabetic polyneuropathy are unknown. We conducted a global metabolomics analysis on plasma samples from a subcohort of participants from the Danish arm of Anglo‐Danish‐Dutch study of Intensive Treatment of Diabetes in Primary Care (ADDITION‐Denmark) with and without diabetic polyneuropathy versus lean control participants. Compared to lean controls, type 2 diabetes participants had significantly higher HbA1c (p = 0.0028), BMI (p = 0.0004), and waist circumference (p = 0.0001), but lower total cholesterol (p = 0.0001). Out of 991 total metabolites, we identified 15 plasma metabolites that differed in type 2 diabetes participants by diabetic polyneuropathy status, including metabolites belonging to energy, lipid, and xenobiotic pathways, among others. Additionally, these metabolites correlated with alterations in plasma lipid metabolites in type 2 diabetes participants based on neuropathy status. Further evaluating all plasma lipid metabolites identified a shift in abundance, chain length, and saturation of free fatty acids in type 2 diabetes participants. Importantly, the presence of diabetic polyneuropathy impacted the abundance of plasma complex lipids, including acylcarnitines and sphingolipids. Our explorative study suggests that diabetic polyneuropathy in type 2 diabetes is associated with novel alterations in plasma metabolites related to lipid metabolism.
登录
查看更多内容
影响因子：
3.5
作者：
Basu Ball W;Neff JK;Gohil VM
通讯作者：
Gohil VM
影响因子：
7.7
作者：
Floegel A;Stefan N;Yu Z;Mühlenbruch K;Drogan D;Joost HG;Fritsche A;Häring HU;Hrabě de Angelis M;Peters A;Roden M;Prehn C;Wang-Sattler R;Illig T;Schulze MB;Adamski J;Boeing H;Pischon T
通讯作者：
Pischon T
周围神经病变与胰岛素抵抗相关，与代谢综合征无关
影响因子：
4.8
作者：
Han L;Ji L;Chang J;Wen J;Zhao W;Shi H;Zhou L;Li Y;Hu R;Hu J;Lu B
通讯作者：
Lu B
影响因子：
5.3
作者：
Breuninger, Taylor A.;Wawro, Nina;Linseisen, Jakob
通讯作者：
Linseisen, Jakob
影响因子：
81.5
作者：
Feldman, Eva L.;Callaghan, Brian C.;Viswanathan, Vijay
通讯作者：
Viswanathan, Vijay