Peripheral neuropathy is associated with insulin resistance independent of metabolic syndrome.
Peripheral neuropathy is associated with insulin resistance independent of metabolic syndrome.
复制标题
周围神经病变与胰岛素抵抗相关，与代谢综合征无关
DOI：
10.1186/s13098-015-0010-y
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发表时间：
2015
影响因子：
4.8
通讯作者：
Lu B
中科院分区：
文献类型：
--
作者：
Han L;Ji L;Chang J;Wen J;Zhao W;Shi H;Zhou L;Li Y;Hu R;Hu J;Lu B
背景：为了确定胰岛素抵抗、代谢综合征（MetS）与周围神经病变（PN）的关系。方法本横断面研究包括2035名上海市受试者，分为有MetS和无MetS。新的国际糖尿病联盟（IDF）标准被用来定义MetS。采用HOMA-IR评价胰岛素抵抗。所有受试者都进行了完整的足部检查。根据神经病变症状和神经病变功能障碍评分评估PN。采用二元logistic回归分析胰岛素抵抗、代谢代谢特征对PN的影响。结果(1)本研究中PN的比例为4.0%。MetS患者（47.7%）有更高的PN百分比（分别为5.5%和2.6%,P = 0.001）。随着MetS成分（非MetS、三、四、五）的增加，周围神经病变的比例呈线性增加（分别为2.6%、4.8%、5.6%和7.2%，P为趋势= 0.001）。(2)有PN患者的平均年龄明显大于相应的非PN患者。met患者中，PN组腰围、空腹血糖、HbA1c、糖尿病及高血压治疗比例均显著高于非PN组。(3)伴有和不伴有MetS的PN患者血糖异常发生率最高（96.2%和82.1%,P = 0.084）。(4)在调整性别和吸烟史后，PN与MetS相关[比值比（OR） 2.0；95%置信区间（CI） 1.2, 3.2；P = 0.006),和年龄(或1.1;95%可信区间1.1,1.1;P < 0.001)。当将HOMA-IR加入二元logistic回归时，PN与MetS的相关性消失（P = 0.110），但PN仍与HOMA-IR相关（OR 1.2; 95% CI 1.1, 1.4, P < 0.001）。结论在代谢综合征中，胰岛素抵抗可能在周围神经病变的发生发展中起重要作用。
BackgroundTo determine the association of insulin resistance, metabolic syndrome (MetS) with peripheral neuropathy (PN).MethodsThis cross-sectional study consisted of 2035 subjects in Shanghai who were classified as with MetS and without MetS. The new International Diabetes Federation (IDF) criterion was used to define MetS. HOMA-IR was applied to evaluate insulin resistance. All subjects underwent complete foot examination. PN was assessed according to the neuropathy symptom and neuropathy disability scores. Binary logistic regression was performed to analyze the contributions of insulin resistance, features of MetS to PN.Results(1) The percentage of PN was 4.0% in our study. Patients with MetS (47.7%) had a higher percentage of PN (5.5% vs. 2.6%, respectively, P = 0.001). With the components of MetS increased (non-MetS, three, four, five), a linear increase in the proportion of peripheral neuropathy was observed (2.6%, 4.8%, 5.6% and 7.2%; respectively, P for trend = 0.001). (2) In patients with PN, the average age of patients was significantly older than the corresponding non-PN patients. Waist circumference, fasting blood glucose, HbA1c, proportion of treatment for diabetes and hypertension were significantly higher in PN group compared with non-PN group in MetS patients. (3) The frequency of dysglycemia was the highest in PN patients both with and without MetS (96.2% and 82.1%, P = 0.084). (4) After adjusting for gender and smoking history, the PN was associated with MetS [odds ratio (OR) 2.0; 95% confidence interval (CI) 1.2, 3.2; P = 0.006], and age (OR 1.1; 95% CI 1.1, 1.1; P < 0.001). When HOMA-IR was added to this binary logistic regression, the association of PN with MetS disappeared (P = 0.110), but the PN was still associated with HOMA-IR (OR 1.2; 95% CI 1.1, 1.4, P < 0.001).ConclusionsIn metabolic syndrome, insulin resistance might play an important role in the development of peripheral neuropathy.
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DOI：
10.1016/j.beem.2006.09.007
发表时间：
2006-12-01
影响因子：
7.4
作者：
Sesti, Giorgio
通讯作者：
Sesti, Giorgio
影响因子：
16.2
作者：
Ford, ES
通讯作者：
Ford, ES
影响因子：
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作者：
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影响因子：
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影响因子：
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Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
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Smith, Sidney C., Jr.