The neurobiology of abstinence-induced reward-seeking in males and females.
The neurobiology of abstinence-induced reward-seeking in males and females.
复制标题
DOI：
10.1016/j.pbb.2020.173088
复制
发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Chartoff EH
中科院分区：
文献类型：
--
作者：
Alonso-Caraballo Y;Guha SK;Chartoff EH
滥用药物和高度适口的食物（例如高脂肪或甜食）具有强大的强化作用，可能导致摄入这些物质的强迫性和成瘾性，达到精神病理学和自残的程度，特别是导致药物使用障碍（SUD）和肥胖。 SUD和暴饮暴食都可以被定义为一种疾病，其中奖励（食物或药物）的重要性相对于其他促进幸福的奖励被夸大，并以牺牲其他奖励为代价。治疗这些疾病的一个主要障碍是禁欲期后复发率很高。尽管不普遍，但常见的是，提示引起的渴望随着禁欲时间的推移而增加，通常是由先前与强化物质配对的提示触发的。越来越多的证据表明，类似的神经回路和细胞机制有助于禁欲诱导和提示触发的对药物和美味食物的寻求。尽管许多研究都集中在皮质边缘回路在药物寻求中的重要作用，但我们的目标是将焦点扩大到最近探索的下丘脑-丘脑-纹状体回路。具体来说，我们回顾了下丘脑外侧、丘脑室旁核和伏核之间的连接和其中的神经递质如何促进戒断诱导的阿片类药物和（高脂肪或甜食）食物的寻求。鉴于生物性别和性腺激素与跨物种的成瘾行为有关，本次综述的另一层内容是在有此类数据的情况下，比较男性和女性之间戒断引起的阿片类药物或食物寻求的行为和基于神经回路的机制。
Drugs of abuse and highly palatable foods (e.g. high fat or sweet foods) have powerful reinforcing effects, which can lead to compulsive and addictive drives to ingest these substances to the point of psychopathology and self-harm--specifically the development of Substance Use Disorder (SUD) and obesity. Both SUD and binge-like overeating can be defined as disorders in which the salience of the reward (food or drug) becomes exaggerated relative to, and at the expense of, other rewards that promote well-being. A major roadblock in the treatment of these disorders is high rates of relapse after periods of abstinence. It is common, although not universal, for cue-induced craving to increase over time with abstinence, often triggered by cues previously paired with the reinforcing substance. Accumulating evidence suggests that similar neural circuits and cellular mechanisms contribute to abstinence-induced and cue-triggered seeking of drugs and palatable food. Although much research has focused on the important role of corticolimbic circuitry in drug-seeking, our goal is to expand focus to the more recently explored hypothalamic–thalamic–striatal circuitry. Specifically, we review how connections, and neurotransmitters therein, among the lateral hypothalamus, paraventricular nucleus of the thalamus, and the nucleus accumbens contribute to abstinence-induced opioid- and (high fat or sweet) food-seeking. Given that biological sex and gonadal hormones have been implicated in addictive behavior across species, another layer to this review is to compare behaviors and neural circuit-based mechanisms of abstinence-induced opioid- or food-seeking between males and females when such data is available.
登录
查看更多内容
DOI：
10.1038/s41386-020-0781-1
发表时间：
2021-03
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Alonso-Caraballo Y;Fetterly TL;Jorgensen ET;Nieto AM;Brown TE;Ferrario CR
通讯作者：
Ferrario CR
影响因子：
5.4
作者：
Aoyama, K.;Barnes, J.;Grimm, J. W.
通讯作者：
Grimm, J. W.
影响因子：
4.9
作者：
Frankort, A.;Roefs, A.;Jansen, A.
通讯作者：
Jansen, A.
DOI：
10.1523/jneurosci.0005-12.2012
发表时间：
2012-04-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bossert JM;Stern AL;Theberge FR;Marchant NJ;Wang HL;Morales M;Shaham Y
通讯作者：
Shaham Y
影响因子：
4.7
作者：
Calu DJ;Chen YW;Kawa AB;Nair SG;Shaham Y
通讯作者：
Shaham Y