Incubation of saccharin craving and within-session changes in responding for a cue previously associated with saccharin.
Incubation of saccharin craving and within-session changes in responding for a cue previously associated with saccharin.
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DOI：
10.1016/j.appet.2013.10.003
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发表时间：
2014-01
期刊：
影响因子：
5.4
通讯作者：
Grimm, J. W.
中科院分区：
文献类型：
--
作者：
Aoyama, K.;Barnes, J.;Grimm, J. W.
在有蔗糖自我给药史的大鼠中，已经描述了在强制戒断后线索诱导的蔗糖寻求的时间依赖性增加，这表明蔗糖渴望“孵育”。在本研究中，我们研究了是否孵化的渴望推广到人工甜味剂，糖精。雄性Long-Evans大鼠31只，每天用0.3%糖精溶液压杆1h，连续10天。在强迫禁欲的第1天或第30天，大鼠对先前在自我给药训练期间每次糖精递送时呈现的音调+光提示的呈现反应1小时。在30天与1天的强制禁欲（“渴望的孵化”）后，大鼠在该线索反应性测试期间的反应更多。这一结果是第一次证明的“孵化的糖精渴望”，并表明，自我管理的摄入后的热量的后果是不是一个必要的条件发展的蔗糖渴望的孵化。我们还研究了在1小时线索反应性测试期间主动杠杆反应的时间过程（会话内减少）。从试验阶段开始，第30天组的大鼠比第1天组的大鼠反应更多。此外，第30天组的反应期内下降斜率比第1天组更浅。这些结果表明，“糖精渴求的孵化”增强了寻求行为的持久性。
Time-dependent increases in cue-induced sucrose seeking after forced abstinence have been described in rats with a history of sucrose self-administration, suggesting sucrose craving “incubates”. In the present study, we examined whether the incubation of craving generalizes to the artificial sweetener, saccharin. Thirty-one male Long-Evans rats lever pressed for 0.3% saccharin solution 1 h/day for 10 days. On either Day 1 or 30 of forced abstinence, rats responded for 1 h for presentation of a tone + light cue previously presented with every saccharin delivery during self-administration training. Rats responded more during this cue-reactivity test session following 30 vs. 1 day of forced abstinence (“incubation of craving”). This result is the first demonstration of the “incubation of saccharin craving” and suggests that a post-ingestive caloric consequence of self-administration is not a necessary condition for the development of incubation of sucrose craving. We also examined the time course (within-session decreases) of active-lever responding during the 1-h cue-reactivity test session. Rats in the Day 30 group responded more than rats in the Day 1 group from the beginning of the test session. In addition, within-session decreases in responding were shallower in slope in the Day 30 than the Day 1 group. These results indicate that “incubation of saccharin craving” enhances the persistence of seeking behavior.
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影响因子：
3.4
作者：
Harkness, John H.;Webb, Sierra;Grimm, Jeffrey W.
通讯作者：
Grimm, Jeffrey W.
DOI：
10.3758/bf03192817
发表时间：
2001-02-01
期刊：
ANIMAL LEARNING & BEHAVIOR
影响因子：
--
作者：
Aoyama, K;McSweeney, FK
通讯作者：
McSweeney, FK
影响因子：
2.9
作者：
Aoyama, K
通讯作者：
Aoyama, K
影响因子：
2.7
作者：
KILLEEN, PR
通讯作者：
KILLEEN, PR
渴望孵化的神经生物学。
影响因子：
15.9
作者：
Pickens, Charles L.;Airavaara, Mikko;Theberge, Florence;Fanous, Sanya;Hope, Bruce T.;Shaham, Yavin
通讯作者：
Shaham, Yavin