Functional architecture of neural circuits for leg proprioception in Drosophila.
Functional architecture of neural circuits for leg proprioception in Drosophila.
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DOI：
10.1016/j.cub.2021.09.035
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发表时间：
2021-12-06
期刊：
影响因子：
--
通讯作者：
Tuthill JC
中科院分区：
文献类型：
--
作者：
Chen C;Agrawal S;Mark B;Mamiya A;Sustar A;Phelps JS;Lee WA;Dickson BJ;Card GM;Tuthill JC
为了有效地控制自己的身体，动物依赖于本体感觉机械感觉神经元的反馈。在果蝇腿部，不同的本体感受器亚型监测关节位置、运动方向和振动。在这里，我们研究了中央本体感觉回路如何整合这些不同的感觉信号。我们发现腿部关节位置和方向运动的信号在二阶神经元中汇聚，揭示了腿部姿势局部反馈控制的途径。不同的二阶神经元群体整合了双腿的胫骨振动信号，这表明在检测外部基底振动中发挥着作用。在每条通路中，感觉信息的流动都是通过抑制动态地门控和塑造的。总的来说，我们的结果揭示了处理内部和外部机械感觉信号的并行途径，我们建议它们分别介导腿部运动和振动传感的反馈控制。功能连接图的存在也为解释腿部本体感觉神经回路的连接组重建提供了资源。为了了解下游电路如何整合来自果蝇腿的不同本体感觉信号，Chen 等人。使用光遗传学和钙成像来绘制感觉神经元和中枢神经元之间的功能连接。这项工作确定了处理腿部振动与关节位置和运动的并行神经通路。
To effectively control their bodies, animals rely on feedback from proprioceptive mechanosensory neurons. In the Drosophila leg, different proprioceptor subtypes monitor joint position, movement direction, and vibration. Here, we investigate how these diverse sensory signals are integrated by central proprioceptive circuits. We find that signals for leg joint position and directional movement converge in second-order neurons, revealing pathways for local feedback control of leg posture. Distinct populations of second-order neurons integrate tibia vibration signals across pairs of legs, suggesting a role in detecting external substrate vibration. In each pathway, the flow of sensory information is dynamically gated and sculpted by inhibition. Overall, our results reveal parallel pathways for processing of internal and external mechanosensory signals, which we propose mediate feedback control of leg movement and vibration sensing, respectively. The existence of a functional connectivity map also provides a resource for interpreting connectomic reconstruction of neural circuits for leg proprioception. To understand how diverse proprioceptive signals from the Drosophila leg are integrated by downstream circuits, Chen et al. use optogenetics and calcium imaging to map functional connectivity between sensory and central neurons. This work identifies parallel neural pathways for processing leg vibration vs. joint position and movement.
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影响因子：
3.3
作者：
Dionne H;Hibbard KL;Cavallaro A;Kao JC;Rubin GM
通讯作者：
Rubin GM
影响因子：
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作者：
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DOI：
10.1073/pnas.1419045111
发表时间：
2014-11-25
影响因子：
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影响因子：
2.5
作者：
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通讯作者：
BURROWS, M