LAMC2 as a prognostic biomarker in human cancer: a systematic review and meta-analysis.
LAMC2 as a prognostic biomarker in human cancer: a systematic review and meta-analysis.
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DOI：
10.1136/bmjopen-2022-063682
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发表时间：
2022-11-17
期刊：
影响因子：
2.9
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中科院分区：
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越来越多的证据表明，层粘连蛋白γ2（LAMC 2）表达水平在各种癌症中上调。然而，LAMC 2在癌症中的潜在预后价值仍不清楚。我们进行了一项荟萃分析，以阐明LAMC 2表达与预后的关系。我们检索Embase、Web of Science和PubMed（截至2021年11月25日），收集所有符合条件的研究，并进行荟萃分析，以解释LAMC 2表达与临床病理参数、总生存期（OS）、疾病特异性生存期（DSS）和无进展生存期（PFS）的相关性。我们纳入了研究LAMC 2与癌症预后关系的研究，将患者分为两组，并描述了LAMC 2表达与临床病理特征的相关性。最终纳入了7项研究。我们发现LAMC 2表达增加与淋巴结转移显著相关，（log OR 0.88，95% CI 0.38至1.38，p<0.001），肿瘤-淋巴结-转移分期（log OR：0.95，95%CI 0.39至1.50，p<0.001）和肿瘤状态（log OR 1.26，95%CI 0.84至1.68，p<0.001），但与年龄（log OR −0.05，95%CI −0.37至0.27，p=0.75）或性别（log OR −0.07，95%CI −0.52至0.38，p=0.75）无关。此外，发现较高的LAMC 2表达与OS/PFS/DSS显著相关（HR 1.85，95%CI 1.31至2.40，p<0.001）。在癌症基因组图谱数据库中也发现了类似的结果。LAMC 2高表达与肺腺癌、间皮瘤、皮肤黑色素瘤、颈部鳞状细胞癌和脑低级别胶质瘤的OS显着相关。我们的研究结果表明，较高的LAMC 2表达与较差的生存率，淋巴结转移，肿瘤淋巴结转移阶段和肿瘤状态相关。这项研究受到固有的局限性，但这里提出的结果提供了关于LAMC 2作为人类癌症生物标志物的潜在用途的见解。researchregistry.com（researchregistry1319）.
Accumulating evidence suggested that the laminin γ2 (LAMC2) expression level was upregulated in various cancers. However, the potential prognostic value of LAMC2 in cancers remains unclear. We conducted a meta-analysis to clarify the association of LAMC2 expression with prognosis. We searched Embase, Web of Science and PubMed (up to 25 November 2021) to collect all eligible studies, and meta-analysis was performed to interpret the association of LAMC2 expression with clinicopathological parameters, overall survival (OS), disease-specific survival (DSS) and progression-free survival (PFS). We included studies that investigate the relationship between LAMC2 and prognosis of cancers, patients were divided into two groups, and associations of LAMC2 expression with clinicopathological features were described. Seven studies were finally included. We found that increased LAMC2 expression was significantly associated with lymph node metastasis (log OR 0.88, 95% CI 0.38 to 1.38, p<0.001), tumour-node-metastasis stages (log OR: 0.95, 95% CI 0.39 to 1.50, p<0.001) and tumour status (log OR 1.26, 95% CI 0.84 to 1.68, p<0.001), but not with age (log OR −0.05, 95% CI −0.37 to 0.27, p=0.75) or gender (log OR −0.07, 95% CI −0.52 to 0.38, p=0.75). In addition, higher LAMC2 expression was found to be significantly associated with OS/PFS/DSS (HR 1.85, 95% CI 1.31 to 2.40, p<0.001). A similar result was found in The Cancer Genome Atlas database. High LAMC2 expression was significantly associated with OS in lung adenocarcinoma, mesothelioma, skin cutaneous melanoma, neck squamous cell carcinoma and brain lower grade glioma. Our results suggested that higher LAMC2 expression was correlated with worse survival, lymph node metastasis, tumour-node-metastasis stages and tumour status. This study was subject to inherent limitations, but the results presented here provide insights regarding the potential use of LAMC2 as a biomarker for human cancer. researchregistry.com (researchregistry1319).
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影响因子：
5.2
作者：
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DOI：
10.1016/j.ejca.2020.12.031
发表时间：
2021-03
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