Intra-axonal protein synthesis in development and beyond.

Intra-axonal protein synthesis in development and beyond.
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轴内蛋白质的发育及其他蛋白质合成。

DOI:
10.1016/j.ijdevneu.2016.03.004
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发表时间:
2016-12
期刊:
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
影响因子:
--
通讯作者:
Hengst U
Hengst U
中科院分区:
其他
文献类型:
--
作者:
Batista AF;Hengst U

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Proteins can be locally produced in the periphery of a cell, allowing a rapid and spatially precise response to the changes in its environment. This process is especially relevant in highly polarized and morphologically complex cells such as neurons. The study of local translation in axons has evolved from being primarily focused on developing axons, to the notion that also mature axons can produce proteins. Axonal translation has been implied in several physiological and pathological conditions, and in all cases it shares common molecular actors and pathways as well as regulatory mechanisms. Here, we review the main findings in these fields, and attempt to highlight shared principles.
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