Rapid Transmission of a Hyper-Virulent Meningococcal Clone Due to High Effective Contact Numbers and Super Spreaders.
Rapid Transmission of a Hyper-Virulent Meningococcal Clone Due to High Effective Contact Numbers and Super Spreaders.
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DOI：
10.3389/fgene.2020.579411
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发表时间：
2020
影响因子：
3.7
通讯作者：
Bayliss CD
中科院分区：
文献类型：
--
作者：
Holmes JC;Green LR;Oldfield NJ;Turner DPJ;Bayliss CD
快速传播是侵袭性脑膜炎球菌病暴发的一个关键因素，需要naïve足够规模和混合的种群。我们研究了高毒性脑膜炎奈瑟菌血清群W ST-11克隆携带增加11倍的学生群体的基因组变异性和传播动力学。系统发育集群、突变和重组率通过全基因组测序数据的生物信息学分析得出。通过简单的SIS模型，结合观察到的运输率、集群大小和分布来确定传播动态。在7个宿舍楼中检测到9到15个遗传上不同的集群。集群突变积累率低，重组事件不常见。模型显示，在大学学期开始和中期之间，有效接触从每天10次减少到每天2次。传播率在1 - 4%之间波动，携带的R(t)从最初的47下降到1。传播值的降低与疫苗诱导免疫力的提高有关。观察到的携带动力学可以被含有20%的超级传播者的种群模拟，有效接触率提高2.3倍。我们得出结论，这种高毒性ST-11脑膜炎球菌克隆的传播取决于有效接触和免疫水平，而不是基因组变异性。此外，我们认为超级传播者增强了脑膜炎球菌的传播，70%的MenACWY免疫水平足以延缓（但不能完全预防）脑膜炎球菌在密切接触人群中的传播。
Rapid transmission, a critical contributory factor in outbreaks of invasive meningococcal disease, requires naïve populations of sufficient size and intermingling. We examined genomic variability and transmission dynamics in a student population subject to an 11-fold increase in carriage of a hypervirulent Neisseria meningitidis serogroup W ST-11 clone. Phylogenetic clusters, mutation and recombination rates were derived by bioinformatic analyses of whole-genome sequencing data. Transmission dynamics were determined by combining observed carriage rates, cluster sizes and distributions with simple SIS models. Between 9 and 15 genetically-distinct clusters were detected and associated with seven residential halls. Clusters had low mutation accumulation rates and infrequent recombination events. Modeling indicated that effective contacts decreased from 10 to 2 per day between the start and mid-point of the university term. Transmission rates fluctuated between 1 and 4% while the R(t) for carriage decreased from an initial rate of 47 to 1. Decreases in transmission values correlated with a rise in vaccine-induced immunity. Observed carriage dynamics could be mimicked by populations containing 20% of super spreaders with 2.3-fold higher effective contact rates. We conclude that spread of this hypervirulent ST-11 meningococcal clone depends on the levels of effective contacts and immunity rather than genomic variability. Additionally, we propose that super-spreaders enhance meningococcal transmission and that a 70% MenACWY immunization level is sufficient to retard, but not fully prevent, meningococcal spread in close-contact populations.
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DOI：
10.1093/bioinformatics/btp347
发表时间：
2009-08-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Assefa S;Keane TM;Otto TD;Newbold C;Berriman M
通讯作者：
Berriman M
影响因子：
8
作者：
Cohn, Amanda C.;MacNeil, Jessica R.;Messonnier, Nancy E.
通讯作者：
Messonnier, Nancy E.
影响因子：
5.3
作者：
Martin DP;Murrell B;Golden M;Khoosal A;Muhire B
通讯作者：
Muhire B
影响因子：
64.8
作者：
Lloyd-Smith JO;Schreiber SJ;Kopp PE;Getz WM
通讯作者：
Getz WM
DOI：
10.1093/bioinformatics/btp348
发表时间：
2009-08-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Capella-Gutiérrez S;Silla-Martínez JM;Gabaldón T
通讯作者：
Gabaldón T