Contributions of neuroimmune and gut-brain signaling to vulnerability of developing substance use disorders.
Contributions of neuroimmune and gut-brain signaling to vulnerability of developing substance use disorders.
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DOI：
10.1016/j.neuropharm.2021.108598
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发表时间：
2021-07-01
影响因子：
4.7
通讯作者：
Kiraly DD
中科院分区：
文献类型：
--
作者：
Lucerne KE;Osman A;Meckel KR;Kiraly DD
流行病学和临床研究表明，只有一部分接触滥用药物的人会继续发展为药物使用障碍。许多因素影响个人对药物使用障碍的易感性，包括内在的生物因素、环境因素和人际/社会因素。鉴于物质使用障碍造成的广泛发病率和死亡率，大量研究侧重于了解导致从最初药物使用转向病理性药物使用的风险因素。了解这些风险因素为制定风险缓解战略提供了一条明确的途径，以帮助减轻人口中物质使用障碍的负担。在这里，我们将回顾快速增长的文献，这些文献考察了外周免疫系统、肠道微生物组和中枢神经系统(CNS)之间的相互作用在调节向病理性药物使用的过渡过程中的重要性。虽然这些系统长期以来一直被视为不同的系统，但越来越多的证据表明，免疫系统和肠道微生物群之间存在双向沟通，推动与物质使用障碍相关的神经和行为可塑性的变化。此外，这两个系统都对环境扰动高度敏感，并与许多神经精神疾病有关。虽然研究物质使用障碍中的这些相互作用还处于相对初级阶段，但澄清肠道免疫大脑信号与物质使用障碍之间的关系有可能提高我们对个人成瘾倾向的理解，并对潜在的治疗方案产生重要的洞察。
Epidemiology and clinical research indicate that only a subset of people who are exposed to drugs of abuse will go on to develop a substance use disorder. Numerous factors impact individual susceptibility to developing a substance use disorder, including intrinsic biological factors, environmental factors, and interpersonal/social factors. Given the extensive morbidity and mortality that is wrought as a consequence of substance use disorders, a substantial body of research has focused on understanding the risk factors that mediate the shift from initial drug use to pathological drug use. Understanding these risk factors provides a clear path for the development of risk mitigation strategies to help reduce the burden of substance use disorders in the population. Here we will review the rapidly growing body of literature that examines the importance of interactions between the peripheral immune system, the gut microbiome, and the central nervous system (CNS) in mediating the transition to pathological drug use. While these systems had long been viewed as distinct, there is growing evidence that there is bidirectional communication between both the immune system and the gut microbiome that drive changes in neural and behavioral plasticity relevant to substance use disorders. Further, both of these systems are highly sensitive to environmental perturbations and are implicated in numerous neuropsychiatric conditions. While the field of study examining these interactions in substance use disorders is in its relative infancy, clarifying the relationship between gut-immune-brain signaling and substance use disorders has potential to improve our understanding of individual propensity to developing addiction and yield important insight into potential treatment options.
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DOI：
10.1016/j.bbi.2017.08.012
发表时间：
2018-01
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Brown KT;Levis SC;O'Neill CE;Northcutt AL;Fabisiak TJ;Watkins LR;Bachtell RK
通讯作者：
Bachtell RK
影响因子：
2.5
作者：
Chen H;Uz T;Manev H
通讯作者：
Manev H
影响因子：
17.1
作者：
Aagaard K;Ma J;Antony KM;Ganu R;Petrosino J;Versalovic J
通讯作者：
Versalovic J
影响因子：
15.1
作者：
Bland, Sondra T.;Hutchinson, Mark R.;Maier, Steven F.;Watkins, Linda R.;Johnson, Kirk W.
通讯作者：
Johnson, Kirk W.
影响因子：
4.6
作者：
Chivero, Ernest T.;Ahmad, Rizwan;Buch, Shilpa
通讯作者：
Buch, Shilpa