Presence of three different paternal lineages among North Indians: a study of 560 Y chromosomes.
Presence of three different paternal lineages among North Indians: a study of 560 Y chromosomes.
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DOI：
10.1080/03014460802558522
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发表时间：
2009-01
影响因子：
1.7
通讯作者：
Agrawal S
中科院分区：
文献类型：
--
作者：
Zhao Z;Khan F;Borkar M;Herrera R;Agrawal S
10亿印度人的遗传结构、亲缘关系和多样性，对于人类种群的进化和塑造当代遗传变异模式的力量等许多尚未回答的问题，具有重要的关键作用。虽然最近有几项关于南印度种姓群体、北印度种姓群体和南印度穆斯林使用Y染色体标记的研究，但总体而言，与其他地理群体相比，印度人口仍然没有得到很好的研究。特别是，没有对来自印度北部的什叶派和逊尼派进行遗传研究。本研究旨在调查北印度人的遗传变异和基因库。共32个Y染色体标记在560北印度男性收集的三个较高的种姓群体（婆罗门，Chaturvedis和Bhargavas）和两个穆斯林群体（什叶派和逊尼派）进行基因分型。根据13个单倍群，揭示了三个不同的谱系。第一个是中亚血统，拥有单倍群R1和R2。第二个谱系是中东起源的单倍群J2*，什叶派特有的E1 b1 b1，并在一定程度上G* 和L*。第三个是土著印第安人Y-谱系，以单倍群H1*、F*、C* 和O* 为代表。E1 b1 b1单倍型仅见于什叶派。结果显示，今天的北印度父系基因库的很大一部分是由中亚血统谁是印欧语系的发言者，这表明现存的印度种姓群体主要是印欧移民的后代。在这项研究中首次报道的什叶派单倍群E的存在，表明两个印度穆斯林教派之间的遗传差异。本研究的结果提供了对史前和早期历史移民到印度的模式和印度人口在近代历史上的演变的见解。
The genetic structure, affinities, and diversity of the 1 billion Indians hold important keys to numerous unanswered questions regarding the evolution of human populations and the forces shaping contemporary patterns of genetic variation. Although there have been several recent studies of South Indian caste groups, North Indian caste groups, and South Indian Muslims using Y-chromosomal markers, overall, the Indian population has still not been well studied compared to other geographical populations. In particular, no genetic study has been conducted on Shias and Sunnis from North India. This study aims to investigate genetic variation and the gene pool in North Indians. A total of 32 Y-chromosomal markers in 560 North Indian males collected from three higher caste groups (Brahmins, Chaturvedis and Bhargavas) and two Muslims groups (Shia and Sunni) were genotyped. Three distinct lineages were revealed based upon 13 haplogroups. The first was a Central Asian lineage harbouring haplogroups R1 and R2. The second lineage was of Middle-Eastern origin represented by haplogroups J2*, Shia-specific E1b1b1, and to some extent G* and L*. The third was the indigenous Indian Y-lineage represented by haplogroups H1*, F*, C* and O*. Haplogroup E1b1b1 was observed in Shias only. The results revealed that a substantial part of today’s North Indian paternal gene pool was contributed by Central Asian lineages who are Indo-European speakers, suggesting that extant Indian caste groups are primarily the descendants of Indo-European migrants. The presence of haplogroup E in Shias, first reported in this study, suggests a genetic distinction between the two Indo Muslim sects. The findings of the present study provide insights into prehistoric and early historic patterns of migration into India and the evolution of Indian populations in recent history.
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影响因子：
9.2
作者：
Cordaux, R;Aunger, R;Stoneking, M
通讯作者：
Stoneking, M
影响因子：
5.3
作者：
Cinnioglu, C;King, R;Underhill, PA
通讯作者：
Underhill, PA
DOI：
10.1073/pnas.0507714103
发表时间：
2006-01-24
影响因子：
11.1
作者：
Sahoo, S;Singh, A;Kashyap, VK
通讯作者：
Kashyap, VK
影响因子：
10.7
作者：
SAITOU, N;NEI, M
通讯作者：
NEI, M
影响因子：
9.8
作者：
Kivisild, T;Rootsi, S;Villems, R
通讯作者：
Villems, R