An exploratory analysis of common genetic variants in the vitamin D pathway including genome-wide associated variants in relation to glioma risk and outcome.
An exploratory analysis of common genetic variants in the vitamin D pathway including genome-wide associated variants in relation to glioma risk and outcome.
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DOI：
10.1007/s10552-012-0018-7
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发表时间：
2012-09
影响因子：
2.3
通讯作者：
Egan, Kathleen M.
中科院分区：
文献类型：
--
作者：
Anic, Gabriella M.;Thompson, Reid C.;Nabors, L. Burton;Olson, Jeffrey J.;Browning, James E.;Madden, Melissa H.;Murtagh, F. Reed;Forsyth, Peter A.;Egan, Kathleen M.
实验和流行病学证据表明维生素D在癌症中的有益作用。体外证据与胶质瘤中的类似保护功能一致;然而，尚未有研究检查维生素D在胶质瘤中的潜在作用。我们评估了622例新诊断的胶质瘤病例和628例健康对照者中维生素D途径常见遗传变异与胶质瘤风险和患者结局之间的相关性，这些病例参加了一项基于临床的病例对照研究。对受试者进行了维生素D受体7个候选和标记单核苷酸多态性的基因分型，以及在全基因组关联研究中与维生素D血清浓度相关的NADSYN 1、GC、CYP 24 A1、CYP 2 R1和C10 ORF 88中的8个额外变体。根据维生素D基因型，使用非条件logistic回归估计年龄和性别调整的比值比和胶质瘤风险的95%置信区间。比例风险回归用于估计320例诊断为高级别肿瘤的患者中神经胶质瘤相关死亡的风险比。多重比较的P值未校正。星形细胞肿瘤的风险与rs3829251（NADSYN 1）、rs 10741657（CYP 2 R1）、rs 2228570（Fok 1，VDR）和rs731236（Taq 1，VDR）中的变异等位基因相关。在少突胶质细胞肿瘤中未发现风险相关性。根据rs 1544410（Bsm 1，VDR）和rs6013897（CYP 24 A1）的变异状态观察生存相关性。这项探索性分析提供了有限的证据，证明维生素D途径基因的遗传变异与胶质瘤风险和生存率有关。
Experimental and epidemiological evidence shows a beneficial role of vitamin D in cancer. In vitro evidence is consistent with a similar protective function in glioma; however, no study has yet examined the potential role of vitamin D in glioma. We evaluated the association between common genetic variants in the vitamin D pathway and glioma risk and patient outcome in 622 newly diagnosed glioma cases and 628 healthy controls enrolled in a clinic-based case–control study. Subjects were genotyped for 7 candidate and tagging single nucleotide polymorphisms in the vitamin D receptor and 8 additional variants in NADSYN1, GC, CYP24A1, CYP2R1, and C10ORF88 linked in genome-wide association studies to serum concentrations of vitamin D. Unconditional logistic regression was used to estimate age- and gender-adjusted odds ratios and 95 % confidence intervals for glioma risk according to vitamin D genotypes. Proportional hazards regression was used to estimate hazard ratios for glioma-related death among 320 patients diagnosed with high-grade tumors. P values were uncorrected for multiple comparisons. Risk of astrocytic tumors was associated with variant alleles in rs3829251 (NADSYN1), rs10741657 (CYP2R1), rs2228570 (Fok1, VDR), and rs731236 (Taq1, VDR). No risk associations were found among oligodendroglial tumors. Survival associations were observed according to variant status for rs1544410 (Bsm1, VDR) and rs6013897 (CYP24A1). This exploratory analysis provides limited evidence of a role for genetic variation in vitamin D pathway genes with glioma risk and survival.
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影响因子：
30.8
作者：
Shete S;Hosking FJ;Robertson LB;Dobbins SE;Sanson M;Malmer B;Simon M;Marie Y;Boisselier B;Delattre JY;Hoang-Xuan K;El Hallani S;Idbaih A;Zelenika D;Andersson U;Henriksson R;Bergenheim AT;Feychting M;Lönn S;Ahlbom A;Schramm J;Linnebank M;Hemminki K;Kumar R;Hepworth SJ;Price A;Armstrong G;Liu Y;Gu X;Yu R;Lau C;Schoemaker M;Muir K;Swerdlow A;Lathrop M;Bondy M;Houlston RS
通讯作者：
Houlston RS
影响因子：
3.5
作者：
Ahn J;Yu K;Stolzenberg-Solomon R;Simon KC;McCullough ML;Gallicchio L;Jacobs EJ;Ascherio A;Helzlsouer K;Jacobs KB;Li Q;Weinstein SJ;Purdue M;Virtamo J;Horst R;Wheeler W;Chanock S;Hunter DJ;Hayes RB;Kraft P;Albanes D
通讯作者：
Albanes D
影响因子：
2.3
作者：
Davies, John R.;Chang, Yu-Mei;Snowden, Helen;Chan, May;Leake, Susan;Karpavicius, Birute;Haynes, Sue;Kukalizch, Kairen;Randerson-Moor, Juliette;Elliott, Faye;Barth, Julian;Kanetsky, Peter A.;Harland, Mark;Bishop, D. Timothy;Barrett, Jennifer H.;Newton-Bishop, Julia A.
通讯作者：
Newton-Bishop, Julia A.
影响因子：
168.9
作者：
Wang, Thomas J.;Zhang, Feng;Richards, J. Brent;Kestenbaum, Bryan;van Meurs, Joyce B.;Berry, Diane;Kiel, Douglas P.;Streeten, Elizabeth A.;Ohlsson, Claes;Koller, Daniel L.;Peltonen, Leena;Cooper, Jason D.;O'Reilly, Paul F.;Houston, Denise K.;Glazer, Nicole L.;Vandenput, Liesbeth;Peacock, Munro;Shi, Julia;Rivadeneira, Fernando;McCarthy, Mark I.;Anneli, Pouta;de Boer, Ian H.;Mangino, Massimo;Kato, Bernet;Smyth, Deborah J.;Booth, Sarah L.;Jacques, Paul F.;Burke, Greg L.;Goodarzi, Mark;Cheung, Ching-Lung;Wolf, Myles;Rice, Kenneth;Goltzman, David;Hidiroglou, Nick;Ladouceur, Martin;Wareham, Nicholas J.;Hocking, Lynne J.;Hart, Deborah;Arden, Nigel K.;Cooper, Cyrus;Malik, Suneil;Fraser, William D.;Hartikainen, Anna-Liisa;Zhai, Guangju;Macdonald, Helen M.;Forouhi, Nita G.;Loos, Ruth J. F.;Reid, David M.;Hakim, Alan;Dennison, Elaine;Liu, Yongmei;Power, Chris;Stevens, Helen E.;Jaana, Laitinen;Vasan, Ramachandran S.;Soranzo, Nicole;Bojunga, Joerg;Psaty, Bruce M.;Lorentzon, Mattias;Foroud, Tatiana;Harris, Tamara B.;Hofman, Albert;Jonsson, John-Olov;Cauley, Jane A.;Uitterlinden, Andre G.;Gibson, Quince;Jarvelin, Marjo-Riitta;Karasik, David;Siscovick, David S.;Econs, Michael J.;Kritchevsky, Stephen B.;Florez, Jose C.;Todd, John A.;Dupuis, Josee;Hyppoenen, Elina;Spector, Timothy D.
通讯作者：
Spector, Timothy D.
影响因子：
5.6
作者：
Giovannucci, Edward
通讯作者：
Giovannucci, Edward