Late effects in survivors of tandem peripheral blood stem cell transplant for high-risk neuroblastoma.
Late effects in survivors of tandem peripheral blood stem cell transplant for high-risk neuroblastoma.
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DOI：
10.1002/pbc.21683
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发表时间：
2008-11
影响因子：
3.2
通讯作者：
Ginsberg JP
中科院分区：
文献类型：
--
作者：
Hobbie WL;Moshang T;Carlson CA;Goldmuntz E;Sacks N;Goldfarb SB;Grupp SA;Ginsberg JP
越来越多患有晚期神经母细胞瘤的儿童正在获得治愈。我们描述了IV期神经母细胞瘤幸存者的临床晚期效应，所有患者均采用TBI联合自体外周血干细胞抢救进行类似治疗。对1997年至2001年在CHOP治疗的35例神经母细胞瘤患者的病历进行了检查。35例患者中有18例死于疾病进展，4例失访。13名患者继续在我们的多学科癌症生存诊所进行随访，在那里他们由一组评估长期后遗症的亚专家进行评估和监测。收集治疗暴露数据，包括临床医生评估和/或诊断测试确定的TBI和治疗相关后遗症。结果表明，所有13名受试者都存在晚期效应，其中12人患有多种负面后遗症，包括生长激素缺乏症，牙齿问题，骨软骨瘤和听力缺陷等问题，其中大多数的发生率高于以前的报道。这个小队列的研究结果表明，需要对这种强化的儿科癌症治疗进行未来的前瞻性研究，并强调了对这些高危受试者进行医疗干预和长期监测以提高整体生活质量的重要性。
Increasing numbers of children with advanced neuroblastoma are achieving cure. We describe the clinical late effects specific to survivors of stage IV neuroblastoma all similarly treated using tandem autologous peripheral blood stem cell rescue with TBI. The medical records of 35 neuroblastoma patients treated at CHOP between 1997 and 2001 were examined. Eighteen of the 35 patients died of progressive disease, and 4 were lost to follow-up. Thirteen patients continue to follow-up in our Multi-disciplinary Cancer Survivorship Clinic where they are evaluated and monitored by a consistent group of subspecialists that evaluate long-term sequelae. Data on treatment exposures including TBI and treatment related sequelae identified by clinician assessment and/or diagnostic testing were collected. Results indicate late effects were present in all 13 subjects, 12 of whom suffered from multiple negative sequelae, including issues with growth hormone deficiency, dental problems, osteochondromas and hearing deficiencies, among others, most at higher rates than reported previously. The findings in this small cohort indicate the need for future prospective studies of this intensive pediatric cancer treatment, and underscore the importance of medical intervention and long-term monitoring of these at-risk subjects to increase overall quality-of-life.
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影响因子：
4.8
作者：
Trahair, T. N.;Vowels, M. R.;Marshall, G. M.
通讯作者：
Marshall, G. M.
影响因子：
3.2
作者：
Laverdière, C;Cheung, NKV;Sklar, CA
通讯作者：
Sklar, CA
影响因子：
2.3
作者：
Marcovici, Peter A.;Berdon, Walter E.;Liebling, Melissa S.
通讯作者：
Liebling, Melissa S.
影响因子：
45.3
作者：
Grupp, SA;Stern, JW;Diller, L
通讯作者：
Diller, L
影响因子：
5.1
作者：
WILLI, SM;COOKE, K;MOSHANG, T
通讯作者：
MOSHANG, T