Comparison of material properties of heel pad between adults with and without type 2 diabetes history: An in-vivo investigation during gait.
Comparison of material properties of heel pad between adults with and without type 2 diabetes history: An in-vivo investigation during gait.
复制标题
有和无 2 型糖尿病史的成年人足跟垫材料特性的比较：步态期间的体内研究。
DOI：
10.3389/fendo.2022.894383
复制
发表时间：
2022
影响因子：
5.2
通讯作者：
Geng, Xiang
中科院分区：
文献类型：
--
作者：
Yang, Xiong-gang;Teng, Zhao-lin;Zhang, Zhen-ming;Wang, Kan;Huang, Ran;Chen, Wen-ming;Wang, Chen;Chen, Li;Zhang, Chao;Huang, Jia-zhang;Wang, Xu;Ma, Xin;Geng, Xiang
本研究旨在比较糖尿病患者和健康成人足跟垫的材料性能，探讨压缩负荷史和糖尿病病程长短对足跟垫材料性能的影响。双透视成像系统（DFIS）和动态足-地接触压力测试板用于测量材料特性，包括初始厚度，峰值应变，峰值应力，刚度，粘性模量和能量耗散率（EDR），在零时间和连续加载后。健康成人和DM患者之间的材料性能进行了比较，在时间零和以下连续负重。然后，比较零时材料性能和连续加载后的性能，以确定加载历史依赖的足跟垫的生物力学行为。然后进行基于亚组的敏感性分析，以研究糖尿病病程（<10年vs. ≥10年）对足跟垫材料性能的影响。入选10例II型糖尿病受试者（20条腿），年龄59 - 73岁（平均：67.8 ± 4.9），和10例年龄匹配的健康成人（20条腿），年龄59 - 72岁（平均：64.4 ± 3.4）。糖尿病史被证明与原发厚度显著降低相关（t=3.18，p=0.003**），峰值应变较高（t=2.41，p=0.021*），刚度较低（w=283，p=0.024*）和较低的粘性模量（w=331，p<0.001*），并且原发厚度显著降低（t=3.30，p=0.002**），在连续加载后较高的峰值应变（w=120，p=0.031*）和较低的粘性模量（t=3.42，p=0.002**）。连续加载与显著降低的原发厚度相关（配对-w =204，p<0.001***）和粘性模量（配对t =5.45，p<0.001*），并且原发厚度显著降低糖尿病组中的配对-w =206，p<0.001*）和粘性模量（配对-t =7.47，p<0.001*）。根据糖尿病病程长短进行亚组分析（<10年vs. ≥10年）时未发现任何显著差异，但回归分析显示糖尿病病程长短与0时（r=0.506，p<0.050）和持续负荷后（r=0.584，p<0.010）的峰值应变呈正相关。发现糖尿病患者与初级厚度和粘性模量降低以及峰值应变增加相关，这可能有助于足跟垫对损伤和溃疡的脆弱性。在足跟垫的软组织中可观察到预压历史依赖性行为，具有降低的初级厚度和粘性模量。
This study was aimed to compare the material properties of heel pad between diabetes patients and healthy adults, and investigate the impact of compressive loading history and length of diabetes course on the material properties of heel pad. The dual fluoroscopic imaging system (DFIS) and dynamic foot-ground contact pressure-test plate were used for measuring the material properties, including primary thickness, peak strain, peak stress, stiffness, viscous modulus and energy dissipation ratio (EDR), both at time zero and following continuous loading. Material properties between healthy adults and DM patients were compared both at time zero and following continuous weight bearing. After then, comparison between time-zero material properties and properties following continuous loading was performed to identify the loading history-dependent biomechanical behaviour of heel pad. Subgroup-based sensitivity analysis was then conducted to investigate the diabetes course (<10 years vs. ≥10 years) on the material properties of heel pad. Ten type II DM subjects (20 legs), aged from 59 to 73 (average: 67.8 ± 4.9), and 10 age-matched healthy adults (20 legs), aged from 59 to 72 (average: 64.4 ± 3.4), were enrolled. Diabetes history was demonstrated to be associated with significantly lower primary thickness (t=3.18, p=0.003**), higher peak strain (t=2.41, p=0.021*), lower stiffness (w=283, p=0.024*) and lower viscous modulus (w=331, p<0.001***) at time zero, and significantly lower primary thickness (t=3.30, p=0.002**), higher peak strain (w=120, p=0.031*) and lower viscous modulus (t=3.42, p=0.002**) following continuous loading. The continuous loading was found to be associated with significantly lower primary thickness (paired-w=204, p<0.001***) and viscous modulus (paired-t=5.45, p<0.001***) in healthy adults, and significantly lower primary thickness (paired-w=206, p<0.001***) and viscous modulus (paired-t=7.47, p<0.001***) in diabetes group. No any significant difference was found when conducting the subgroup analysis based on length of diabetes course (<10 years vs. ≥10 years), but the regression analysis showed that the length of diabetes history was positively associated with the peak strain, at time zero (r=0.506, p<0.050) and following continuous loading (r=0.584, p<0.010). Diabetes patients were found to be associated with decreased primary thickness and viscous modulus, and increased peak strain, which may contribute to the vulnerability of heel pad to injury and ulceration. Pre-compression history-dependent behaviour is observable in soft tissue of heel pad, with lowered primary thickness and viscous modulus.
登录
查看更多内容
影响因子：
1.8
作者：
Hsu, TC;Lee, YS;Shau, YW
通讯作者：
Shau, YW
DOI：
10.1016/j.jmbbm.2016.09.003
发表时间：
2017-01
影响因子：
3.9
作者：
Grigoriadis G;Newell N;Carpanen D;Christou A;Bull AMJ;Masouros SD
通讯作者：
Masouros SD
影响因子：
--
作者：
Shalamberidze M;Sokhadze Z;Tatvidze M
通讯作者：
Tatvidze M
影响因子：
1.3
作者：
Cheung, YY;Doyley, M;Weaver, J
通讯作者：
Weaver, J
DOI：
10.1177/107110079201300502
发表时间：
1992-06-01
期刊：
FOOT & ANKLE
影响因子：
--
作者：
JAHSS, MH;MICHELSON, JD;REICH, S
通讯作者：
REICH, S