Non-invasive measurements of carboxyhemoglobin and methemoglobin in children with sickle cell disease.
Non-invasive measurements of carboxyhemoglobin and methemoglobin in children with sickle cell disease.
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DOI：
10.1002/ppul.22504
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发表时间：
2012-08
影响因子：
3.1
通讯作者：
Allen, Julian L.
中科院分区：
文献类型：
--
作者：
Caboot, Jason B.;Jawad, Abbas F.;McDonough, Joseph M.;Bowdre, Cheryl Y.;Arens, Raanan;Marcus, Carole L.;Mason, Thornton B. A.;Smith-Whitley, Kim;Ohene-Frempong, Kwaku;Allen, Julian L.
评估镰状细胞病（SCD）患者的血氧饱和度对于及时识别低氧血症至关重要。在SCD患者中脉搏血氧仪测量血氧的准确性是可变的，部分是由于碳氧血红蛋白（COHb）和高铁血红蛋白（MetHb），它们降低了血液的氧含量。本研究评价了无创脉搏一氧化碳血氧仪测量SCD儿童COHb和MetHb百分比（SpCO和SpMet）的准确性和可靠性。我们假设通过无创脉搏一氧化碳血氧测定法测量的COHb和MetHb与通过有创全血一氧化碳血氧测定法测量的COHb和MetHb在可接受的临床准确度内一致。50名患有SCD-SS的儿童在呼吸室内空气时进行脉搏血氧饱和度测定和血液血氧饱和度测定。将非侵入性COHb和MetHb读数与相应的血液测量值进行比较。脉搏一氧化碳血氧仪偏倚为0.1%（COHb）和-0.22%（MetHb）。在0.4- 6.1%的COHb范围内，SpCO的精密度为±2.1%;在0.1- 1.1%的MetHb范围内，SpMet的精密度为±0.33%。无创脉搏一氧化碳血氧仪可用于测量SCD儿童的COHb和MetHb水平。尽管非侵入性技术略微高估了侵入性COHb测量值，略微低估了侵入性MetHb测量值，但两种方法之间存在密切的一致性。
Assessment of oxyhemoglobin saturation in patients with sickle cell disease (SCD) is vital for prompt recognition of hypoxemia. The accuracy of pulse oximeter measurements of blood oxygenation in SCD patients is variable, partially due to carboxyhemoglobin (COHb) and methemoglobin (MetHb), which decrease the oxygen content of blood. This study evaluated the accuracy and reliability of a non-invasive pulse co-oximeter in measuring COHb and MetHb percentages (SpCO and SpMet) in children with SCD. We hypothesized that measurements of COHb and MetHb by non-invasive pulse co-oximetry agree within acceptable clinical accuracy with those made by invasive whole blood co-oximetry. Fifty children with SCD-SS underwent pulse co-oximetry and blood co-oximetry while breathing room air. Non-invasive COHb and MetHb readings were compared to the corresponding blood measurements. The pulse co-oximeter bias was 0.1% for COHb and −0.22% for MetHb. The precision of the measured SpCO was ±2.1% within a COHb range of 0.4–6.1%, and the precision of the measured SpMet was ±0.33% within a MetHb range of 0.1–1.1%. Non-invasive pulse co-oximetry was useful in measuring COHb and MetHb levels in children with SCD. Although the non-invasive technique slightly overestimated the invasive COHb measurements and slightly underestimated the invasive MetHb measurements, there was close agreement between the two methods.
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影响因子：
168.9
作者：
Kirkham, FJ;Hewes, DKM;Evans, JPM
通讯作者：
Evans, JPM
DOI：
10.2307/2987937
发表时间：
1983-01-01
期刊：
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES D-THE STATISTICIAN
影响因子：
--
作者：
ALTMAN, DG;BLAND, JM
通讯作者：
BLAND, JM
影响因子：
20.3
作者：
Hargrave, DR;Wade, A;Kirkham, FJ
通讯作者：
Kirkham, FJ
影响因子：
3.1
作者：
Ahmed, S;Siddiqui, AK;Mattana, J
通讯作者：
Mattana, J
影响因子：
8.8
作者：
Fitzgerald, RK;Johnson, A
通讯作者：
Johnson, A