Maternal immune responses and obstetrical outcomes of pregnant women with COVID-19 and possible health risks of offspring.
Maternal immune responses and obstetrical outcomes of pregnant women with COVID-19 and possible health risks of offspring.
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DOI：
10.1016/j.jri.2020.103250
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发表时间：
2021-03
影响因子：
3.4
通讯作者：
Kwak-Kim J
中科院分区：
文献类型：
--
作者：
Cavalcante MB;Cavalcante CTMB;Sarno M;Barini R;Kwak-Kim J
2019冠状病毒病（COVID-19）大流行在全球迅速蔓延。绝大多数COVID-19患者表现为轻度至中度症状，但可能发展为严重病例甚至死亡。育龄青年是SARS-CoV-2感染的重灾区。然而，怀孕是否会导致COVID-19的严重程度尚未达成共识。对孕妇的初步研究发现，COVID-19显著增加了早产、宫内生长受限和低出生体重的风险，这些风险与后代的非传染性疾病有关。此外，无论是否有垂直传播，母体病毒感染都与后代的神经和行为障碍有关。在这篇综述中，根据现有证据，通过回顾产妇对COVID-19的免疫反应，讨论了感染COVID-19妇女的产科结局及其后代可能面临的风险。建议对宫内暴露于SARS-CoV-2的后代进行结构和系统随访。
Coronavirus disease 2019 (COVID-19) pandemic has spread rapidly across the world. The vast majority of patients with COVID-19 manifest mild to moderate symptoms but may progress to severe cases or even mortalities. Young adults of reproductive age are the most affected population by SARS-CoV-2 infection. However, there is no consensus yet if pregnancy contributes to the severity of COVID-19. Initial studies of pregnant women have found that COVID-19 significantly increases the risk of preterm birth, intrauterine growth restriction, and low birth weight, which have been associated with non-communicable diseases in offspring. Besides, maternal viral infections with or without vertical transmission have been allied with neurological and behavioral disorders of the offspring. In this review, obstetrical outcomes of women with COVID-19 and possible risks for their offspring are discussed by reviewing maternal immune responses to COVID-19 based on the current evidence. Structural and systemic follow-up of offspring who are exposed to SARS-CoV-2 in-utero is suggested.
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影响因子：
9.8
作者：
Brandt JS;Hill J;Reddy A;Schuster M;Patrick HS;Rosen T;Sauer MV;Boyle C;Ananth CV
通讯作者：
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DOI：
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发表时间：
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期刊：
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发表时间：
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期刊：
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2.4
作者：
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