Serological documentation of maternal influenza exposure and bipolar disorder in adult offspring.
Serological documentation of maternal influenza exposure and bipolar disorder in adult offspring.
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DOI：
10.1176/appi.ajp.2013.13070943
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Brown AS
中科院分区：
文献类型：
--
作者：
Canetta SE;Bao Y;Co MD;Ennis FA;Cruz J;Terajima M;Shen L;Kellendonk C;Schaefer CA;Brown AS
本研究的目的是评估血清学证实的母亲暴露于流感是否与后代双相情感障碍的风险增加以及双相情感障碍的亚型（有或无精神病特征）相关。该研究在儿童健康与发育研究出生队列中采用了巢式病例对照设计。85例双相情感障碍患者在广泛的确认和诊断评估后被确定，并与分析中的170例对照组相匹配。使用血凝抑制试验确定母亲暴露于流感的血清学文件。血清学证明母亲接触流感和后代双相情感障碍之间没有关联。然而，母亲血清学流感暴露与双相情感障碍伴精神病特征的风险显著增加5倍相关。这些结果表明，母亲的流感暴露可能会增加风险的后代发展为双相情感障碍与精神病的特点。结合产前流感暴露与精神分裂症之间的早期关联，这可能表明产前流感是精神病的危险因素，而不是特定的精神障碍诊断。
The goal of the present study was to evaluate whether serologically confirmed maternal exposure to influenza is associated with an increased risk of bipolar disorder in the offspring and with subtypes of bipolar disorder, with and without psychotic features. The study utilized a nested case-control design in the Child Health and Development Study birth cohort. Eighty-five cases of bipolar disorder were identified following extensive ascertainment and diagnostic assessment and matched to 170 controls in the analysis. Serological documentation of maternal exposure to influenza was determined using the hemagglutination inhibition assay. There was no association between serologically documented maternal exposure to influenza and bipolar disorder in offspring. However, maternal serologic influenza exposure was related to a significant, fivefold increased risk of bipolar disorder with psychotic features. These results suggest that maternal influenza exposure may increase the risk for the offspring developing bipolar disorder with psychotic features. Taken together with earlier associations between prenatal influenza exposure and schizophrenia, this may suggest that prenatal influenza is a risk factor for psychosis, rather than for a specific psychotic disorder diagnosis.
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