Patterns of antimicrobial agent prescription in a sentinel population of canine and feline veterinary practices in the United Kingdom.
Patterns of antimicrobial agent prescription in a sentinel population of canine and feline veterinary practices in the United Kingdom.
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DOI：
10.1016/j.tvjl.2017.03.010
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Radford AD
中科院分区：
文献类型：
--
作者：
Singleton DA;Sánchez-Vizcaíno F;Dawson S;Jones PH;Noble PJM;Pinchbeck GL;Williams NJ;Radford AD
在两年的时间里(2014-2016)，对英国大量猫狗的抗菌剂处方进行了监测。给猫开全身抗菌剂的频率更高；给狗开局部用药的频率更高。在这个群体中，猫和狗的抗菌剂处方都观察到了时间上的减少(2014-2016)。开给猫的抗菌剂的场所，通常也给狗开的药。最常用的抗生素是猫用的头孢维辛和狗用的克拉维酸增强阿莫西林。抗菌素耐药性是一个日益重要的全球健康威胁，而抗菌剂的使用是其发展的一个关键风险因素。这项研究使用英国457个哨兵兽医场所网络中预约会诊的电子健康记录，描述了两年内抗菌剂处方(AAP)的模式。使用半自动分类方法对413,870只狗的918,333只EHR和200,541只猫的352,730只EHR的从业者定义的产品代码进行了映射，其中包括289,789只AAP。AAP在所有预约会诊中的比例，狗(18.8%，95%可信区间，18.2-19.4)高于猫(17.5%，95%可信区间，16.9-18.1)。开局部抗菌药物的狗(7.4%，95%CI 7.2~7.7)高于猫(3.2%，95%CI 3.1~3.3)，而开全身抗菌药物的猫(14.8%，95%CI 14.2~15.4)高于狗(12.2%，95%CI 11.7~12.7)。在狗和猫的全身抗菌药处方中，发现了一个递减的时间模式。经常给狗开抗菌剂的场所也经常给猫开抗菌剂。AAP在狗的瘙痒咨询和猫的创伤咨询中最常见。克拉维酸增强阿莫西林是狗最常用的抗菌药物(28.6%的处方，95%可信区间为27.4~29.8)，而头孢维辛是猫最常用的抗菌药物(36.2%，95%可信区间为33.9~38.5)。这项研究展示了AAP随着时间的推移以及英国同伴动物种群中不同条件下的模式。
Antimicrobial agent prescription was monitored in a large UK population of cats and dogs over a 2 year period (2014–2016). Systemic antimicrobial agents were prescribed more frequently to cats; topical prescription was more frequent in dogs. A temporal reduction (2014–2016) in antimicrobial agent prescription was observed in both cats and dogs in this population. Premises which prescribed antimicrobial agents commonly to cats generally also prescribed commonly to dogs. The most frequently prescribed antibiotics were cefovecin in cats and clavulanic acid potentiated amoxicillin in dogs. Antimicrobial resistance is an increasingly important global health threat and the use of antimicrobial agents is a key risk factor in its development. This study describes antimicrobial agent prescription (AAP) patterns over a 2 year period using electronic health records (EHRs) from booked consultations in a network of 457 sentinel veterinary premises in the United Kingdom. A semi-automated classification methodology was used to map practitioner defined product codes in 918,333 EHRs from 413,870 dogs and 352,730 EHRs from 200,541 cats, including 289,789 AAPs. AAP as a proportion of total booked consultations was more frequent in dogs (18.8%, 95% confidence interval, CI, 18.2–19.4) than cats (17.5%, 95% CI 16.9–18.1). Prescription of topical antimicrobial agents was more frequent in dogs (7.4%, 95% CI 7.2–7.7) than cats (3.2%, 95% CI 3.1–3.3), whilst prescription of systemic antimicrobial agents was more frequent in cats (14.8%, 95% CI 14.2–15.4) than dogs (12.2%, 95% CI 11.7–12.7). A decreasing temporal pattern was identified for prescription of systemic antimicrobial agents in dogs and cats. Premises which prescribed antimicrobial agents frequently for dogs also prescribed frequently for cats. AAP was most frequent during pruritus consultations in dogs and trauma consultations in cats. Clavulanic acid potentiated amoxicillin was the most frequently prescribed antimicrobial agent in dogs (28.6% of prescriptions, 95% CI 27.4–29.8), whereas cefovecin, a third generation cephalosporin, was the most frequently prescribed antimicrobial agent in cats (36.2%, 95% CI 33.9–38.5). This study demonstrated patterns in AAP over time and for different conditions in a population of companion animals in the United Kingdom.
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影响因子：
2.6
作者：
Summers, Jennifer F.;Hendricks, Anke;Brodbelt, David C.
通讯作者：
Brodbelt, David C.
影响因子：
2.6
作者：
Mateus, Ana L. P.;Brodbelt, David C.;Staerk, Katharina D. C.
通讯作者：
Staerk, Katharina D. C.
影响因子：
2.2
作者：
O'Neill, D. G.;Church, D. B.;Brodbelt, D. C.
通讯作者：
Brodbelt, D. C.
影响因子：
4.4
作者：
Magalhaes, Ricardo Jorge Soares;Loeffler, Anette;Pfeiffer, Dirk Udo
通讯作者：
Pfeiffer, Dirk Udo
影响因子：
1.7
作者：
Burke, Sara;Black, Vicki;Tasker, Severine
通讯作者：
Tasker, Severine