Beyond age and gender: relationships between cortical and subcortical brain volume and cognitive-motor abilities in school-age children.
Beyond age and gender: relationships between cortical and subcortical brain volume and cognitive-motor abilities in school-age children.
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DOI：
10.1016/j.neuroimage.2010.11.021
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发表时间：
2011-02-14
期刊：
影响因子：
5.7
通讯作者：
Haufler AJ
中科院分区：
文献类型：
--
作者：
Pangelinan MM;Zhang G;VanMeter JW;Clark JE;Hatfield BD;Haufler AJ
越来越多的证据表明，认知和运动功能是相互关联的，并且可能依赖于相同的皮层和皮层下神经结构的发育。然而，迄今为止还没有研究调查正常发育儿童的脑容量、认知能力和运动能力之间的关系。美国国立卫生研究院正常大脑发育的MRI研究包括一个大型的、纵向的结构MRI数据库，以及来自典型发育儿童的一系列神经心理学评估的表现测量。这个数据集为研究大脑和认知运动能力之间的关系提供了一个独特的机会。对172名6至13岁儿童的数据进行了二次分析，共进行了两次测量（初次测试和2年随访）。采用线性混合效应模型来解释年龄和性别对特定皮层和皮层下体积发育的影响，以及感兴趣的行为表现指标。除了年龄和性别的影响外，一般认知能力（IQ）与大脑皮层下结构（小脑和尾状核）以及空间工作记忆和壳核的体积之间存在显著关系。此外，研究还发现，智商与全球和额叶灰质体积以及顶叶灰质和白质有关。在行为水平上，一般认知能力也与视觉运动能力（钉板）和执行功能（空间工作记忆）有关。这些结果支持了认知和运动技能可能在行为和大脑结构两个层面上根本相关的观点。
There is growing evidence that cognitive and motor functions are interrelated and may rely on the development of the same cortical and subcortical neural structures. However, no study to date has examined the relationships between brain volume, cognitive ability, and motor ability in typically developing children. The NIH MRI Study of Normal Brain Development consists of a large, longitudinal database of structural MRI and performance measures from a battery of neuropsychological assessments from typically developing children. This dataset provides a unique opportunity to examine relationships between the brain and cognitive-motor abilities. A secondary analysis was conducted on data from 172 children between the ages of 6 to 13 years with up to 2 measurement occasions (initial testing and 2-year follow-up). Linear mixed effects modeling was employed to account for age and gender effects on the development of specific cortical and subcortical volumes as well as behavioral performance measures of interest. Above and beyond the effects of age and gender, significant relationships were found between general cognitive ability (IQ) and the volume of subcortical brain structures (cerebellum and caudate) as well as spatial working memory and the putamen. In addition, IQ was found to be related to global and frontal gray matter volume as well as parietal gray and white matter. At the behavioral level, general cognitive ability was also found to be related to visuomotor ability (pegboard) and executive function (spatial working memory). These results support the notion that cognition and motor skills may be fundamentally interrelated at both the levels of behavior and brain structure.
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影响因子：
2.6
作者：
Davis, Andrew S.;Pass, Lisa A.;Woodcock, Richard W.
通讯作者：
Woodcock, Richard W.
DOI：
10.1080/15374417909532912
发表时间：
1979-01-01
期刊：
JOURNAL OF CLINICAL CHILD PSYCHOLOGY
影响因子：
--
作者：
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通讯作者：
BROMAN, M
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作者：
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通讯作者：
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影响因子：
120.7
作者：
Castellanos, FX;Lee, PP;Rapoport, JL
通讯作者：
Rapoport, JL
影响因子：
16.2
作者：
Bunge, SA;Dudukovic, NM;Gabrieli, JDE
通讯作者：
Gabrieli, JDE