A self-assembled amphiphilic polysaccharide-based co-delivery system for egg white derived peptides and curcumin with oral bioavailability enhancement.
A self-assembled amphiphilic polysaccharide-based co-delivery system for egg white derived peptides and curcumin with oral bioavailability enhancement.
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一种基于两亲性多糖的自组装共递送系统，用于蛋清衍生肽和姜黄素，并增强口服生物利用度。
DOI：
10.1039/d1fo01649k
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发表时间：
2021-09
期刊：
影响因子：
6.1
通讯作者：
Du Zhiyang
中科院分区：
文献类型：
--
作者：
Yang Meng;Liu Jingbo;Li Yajuan;Yang Qi;Liu Xuanting;Liu Chunmei;Ma Sitong;Liu Boqun;Zhang Ting;Xiao Hang;Du Zhiyang
蛋清衍生肽（EWDP）和姜黄素因具有多种生物活性而闻名，但这两种天然营养保健品的组合使用因其低口服生物利用度和明显不同的极性而受到极大限制。因此，本研究旨在开发一种简便的自组装两亲系统，用于亲水性蛋清衍生肽（EWDP）和疏水性姜黄素的口服共同递送。首先将疏水性姜黄素负载到作为核心的β-环糊精（β-CD）的疏水空腔中。然后，亲水性的EWDP被吸收到核和N-[(2-羟基-3-三甲基铵)丙基]壳聚糖(HTCC)壳之间的区域，通过层层自组装形成两亲性纳米颗粒(NPs)。所得纳米颗粒在 pH 2.0-7.0 下表现出理想的口服适用性、优异的胶体特性以及对 EWDP 和姜黄素的包封能力。 X射线光电子能谱（XPS）、傅里叶变换红外光谱（FTIR）、核磁共振（1H NMR）、X射线衍射（XRD）和差示扫描量热（DSC）结果表明，氢键和疏水相互作用是两亲性纳米粒子形成的主要驱动力。与 HTCC 结合后，EWDP（壳材料和核心营养制品）可以促进姜黄素加载到更深的 β-CD 空腔部位，并具有令人赞叹的溶解度改善。此外，与简单混合物和传统姜黄素包合物相比，EWDP 和姜黄素共同递送后表现出优异的生物利用度（特别是生物活性和细胞吸收）。总体而言，这些发现对于食品和相关健康促进领域中更广泛的亲水性和疏水性营养保健品（最初是否具有协同作用）的基于合理肽的口服共递送系统配方具有启发性。
Egg white derived peptides (EWDP) and curcumin are well known for diverse biological activities, but the combinational usage of the two natural nutraceuticals is extremely limited by their low oral bioavailability and distinctly different polarities. Therefore, this study aimed to exploit a facile self-assembled amphiphilic system for oral co-delivery of hydrophilic egg white derived peptides (EWDP) and hydrophobic curcumin. The hydrophobic curcumin was first loaded into the hydrophobic cavity of β-cyclodextrin (β-CD) as a core. Then, the hydrophilic EWDP was absorbed into the region between the core and the N-[(2-hydroxy-3-trimethyl ammonium) propyl] chitosan (HTCC) shell to form the amphiphilic nanoparticles (NPs) via layer-by-layer self-assembly. The resulting NPs showed ideal oral applicability with excellent colloidal properties and encapsulation capacity for EWDP and curcumin at pH 2.0-7.0. X-ray Photoelectron Spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (1H NMR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC) results indicated that hydrogen bonding and hydrophobic interaction were the main driving force for the formation of amphiphilic NPs. Upon combination with HTCC, EWDP (both shell material and core nutraceuticals) could facilitate curcumin loading into the deeper β-CD cavity site with admirable solubility improvement. Moreover, EWDP and curcumin after co-delivery exhibited superior bioavailability (especially for bioactivity and cellular absorption) than the simple mixture and conventional curcumin inclusion complex. Overall, these findings are enlightening for the rational peptide based oral co-delivery system formulations for a broader range of hydrophilic and hydrophobic nutraceuticals (initially synergistic or not) in the food and related health-promoting fields.
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DOI：
10.1016/j.ijbiomac.2020.01.206
发表时间：
2020-03-15
影响因子：
8.2
作者：
Alizadeh, Nina;Malakzadeh, Shokufeh
通讯作者：
Malakzadeh, Shokufeh
影响因子：
6.1
作者：
Ding, Long;Wang, Liying;Liu, Jingbo
通讯作者：
Liu, Jingbo
DOI：
10.1007/s10856-018-6048-2
发表时间：
2018-04-01
影响因子：
3.7
作者：
Piras, Anna Maria;Zambito, Ylenia;Chetoni, Patrizia
通讯作者：
Chetoni, Patrizia
影响因子：
10.2
作者：
Qiong-Qiong Yang-Qiong;Xin-Lin Wei;Yasi Fang;R. Gan;Min Wang;Ying-Ying Ge-Ying;Dan-Wei Zhang;Li-Zeng Cheng-Li-Zeng
通讯作者：
Qiong-Qiong Yang-Qiong;Xin-Lin Wei;Yasi Fang;R. Gan;Min Wang;Ying-Ying Ge-Ying;Dan-Wei Zhang;Li-Zeng Cheng-Li-Zeng
影响因子：
6.1
作者：
Ding, Long;Wang, Liying;Liu, Jingbo
通讯作者：
Liu, Jingbo