Insomnia as a moderator of alcohol use and blackout: Potential role in acute physiological consequences.
Insomnia as a moderator of alcohol use and blackout: Potential role in acute physiological consequences.
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DOI：
10.1016/j.addbeh.2022.107395
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发表时间：
2022-11
影响因子：
4.4
通讯作者：
Froeliger, Brett
中科院分区：
文献类型：
--
作者：
Miller, Mary Beth;Boness, Cassandra L.;DiBello, Angelo M.;Froeliger, Brett
酒精引起的昏厥与酒精相关的危害（包括急诊室就诊和性胁迫）同时和潜在地相关。虽然从经验上看，睡眠与昏厥没有联系，但失眠的症状也与记忆障碍有关，在这种情况下，失眠症状可能会加剧酒精对记忆的负面影响。这项研究测试了失眠症状在大量饮酒和酒精引起的昏迷之间的调节作用。酗酒的大学年轻人（N=461, 69%为女性）在偏远地区完成了在线评估。用层次线性回归检验预测停电频率的调节模型。采用Logistic回归对事后假设进行检验。与我们的主要假设相反，在严重失眠的情况下，大量饮酒与断片的关联更弱（而不是更强）。事后分析测试了失眠症状作为大量饮酒和酒精使用的急性生理后果（昏厥、昏倒、恶心/呕吐和宿醉）之间关联的独特调节因素。失眠的严重程度至少在一定程度上缓和了大量饮酒与酒精使用的5种生理后果中的4种之间的关系，并且仅缓和了饮酒与其余19种后果中的1种之间的关系。失眠的症状与酒精相关的危害有关，但可能会缓和饮酒与酒精急性生理后果之间的联系。需要进一步的研究来确定酒精是否会增加对酒精急性生理效应的敏感性，在这种情况下，患有失眠症的年轻人可能需要更少的酒精来体验这些效应。
Alcohol-induced blackout is associated concurrently and prospectively with alcohol-related harm, including emergency room visits and sexual coercion. Although sleep has not been linked empirically to blackout, symptoms of insomnia have also been linked to memory impairment, in which case insomnia symptoms may compound alcohol’s negative effects on memory. This study tested insomnia symptoms as a moderator of the association between heavy drinking and alcohol-induced blackout. Heavy-drinking young adults in college (N=461, 69% female) completed assessments online from remote locations. Hierarchical linear regression was used to test a moderation model predicting blackout frequency. Logistic regression was used to test post hoc hypotheses. In contrast to our main hypothesis, heavy drinking was more weakly (not more strongly) associated with blackout in the context of more severe insomnia. Post hoc analyses tested insomnia symptoms as a unique moderator of the association between heavy drinking and likelihood of acute physiological consequences of alcohol use (blackout, passing out, nausea/throwing up, and hangover). Insomnia severity at least marginally moderated the association between heavy drinking and 4 out of 5 physiological consequences of alcohol use, and only moderated the association between drinking and 1 of 19 remaining consequences. Symptoms of insomnia are associated with alcohol-related harm, but may buffer the association between drinking and acute physiological consequences of alcohol. Additional research is needed to determine if alcohol heightens sensitivity to the acute physiological effects of alcohol, in which case less alcohol may be required for young adults with insomnia to experience these effects.
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DOI：
10.1002/alz.12405
发表时间：
2022-03
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Baril AA;Beiser AS;Sanchez E;Mysliwiec V;Redline S;Gottlieb DJ;O'Connor GT;Gonzales MM;Himali D;Seshadri S;Himali JJ;Pase MP
通讯作者：
Pase MP
影响因子：
5.9
作者：
Marlatt, GA;Baer, JS;Williams, E
通讯作者：
Williams, E
影响因子：
4.8
作者：
Bastien, Celyne H.;Vallieres, Annie;Morin, Charles M.
通讯作者：
Morin, Charles M.
DOI：
10.1111/acer.14882
发表时间：
2022-08
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Boness, Cassandra L.;Gatten, Natalie;Treece, Mc Kenna;Miller, Mary Beth
通讯作者：
Miller, Mary Beth
影响因子：
3.4
作者：
Kahler, Christopher W.;Hustad, John;Borsari, Brian
通讯作者：
Borsari, Brian