Reduced clot debris size using standing waves formed via high intensity focused ultrasound
Reduced clot debris size using standing waves formed via high intensity focused ultrasound
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利用高强度聚焦超声形成的驻波减少血块碎片尺寸
DOI：
10.1063/1.4994038
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发表时间：
2017-09
影响因子：
4
通讯作者：
Wan Mingxi
中科院分区：
文献类型：
--
作者：
Guo Shifang;Du Xuan;Wang Xin;Lu Shukuan;Shi Aiwei;Xu Shanshan;Bouakaz Ayache;Wan Mingxi
利用高强度聚焦超声（HIFU）诱导溶栓的可行性先前已得到证实。然而，临床关注的仍然是由于原始血块的碎片可能太大，从而阻塞下游血管，导致危险的栓塞。本研究探讨了利用HIFU形成的驻波场来崩解血栓，同时在体外实现减少血栓碎片大小。结果表明，在相同超声溶栓条件下，驻波模式下以体积百分比计算的凝块碎片平均直径小于行波模式。此外，驻波模式下的惯性空化剂量较低，而两种模式下的空化泡大小分布近似。这些结果表明，驻波作用下凝块碎片尺寸的减小可能是由于声罐的粒子捕获。
The feasibility of utilizing high intensity focused ultrasound (HIFU) to induce thrombolysis has been demonstrated previously. However, clinical concerns still remain related to the clot debris produced via fragmentation of the original clot potentially being too large and hence occluding downstream vessels, causing hazardous emboli. This study investigates the use of standing wave fields formed via HIFU to disintegrate the thrombus while achieving a reduced clot debris size in vitro. The results showed that the average diameter of the clot debris calculated by volume percentage was smaller in the standing wave mode than in the travelling wave mode at identical ultrasound thrombolysis settings. Furthermore, the inertial cavitation dose was shown to be lower in the standing wave mode, while the estimated cavitation bubble size distribution was similar in both modes. These results show that a reduction of the clot debris size with standing waves may be attributed to the particle trapping of the acoustic pot...
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