Lysophosphatidic acid receptor type‐1 mediates brain activation in micro‐positron emission tomography analysis in a fibromyalgia‐like mouse model
Lysophosphatidic acid receptor type‐1 mediates brain activation in micro‐positron emission tomography analysis in a fibromyalgia‐like mouse model
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纤维肌痛样小鼠模型中微正电子发射断层扫描分析中溶血磷脂酸受体 1 型介导大脑激活
DOI：
10.1111/ejn.15729
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发表时间：
2022
影响因子：
3.4
通讯作者：
Ueda Hiroshi
中科院分区：
文献类型：
--
作者：
Neyama Hiroyuki;Nishiyori Michiko;Cui Yilong;Watanabe Yasuyoshi;Ueda Hiroshi
间歇性冷应激诱导的全身性疼痛反应与纤维肌痛患者的病理生理和药物治疗特征相似，包括慢性全身性疼痛和女性优势。此外，正如在许多神经性疼痛模型中报道的那样，溶血磷脂酸受体1型敲除小鼠中间歇性冷应激诱导的全身性疼痛被消除。本研究旨在确定参与间歇性冷应激广泛性疼痛反应的脑位点，并测试它们对溶血磷脂酸受体类型- 1的依赖性。使用2 -脱氧- 2 - [18F]氟- d -葡萄糖在疼痛刺激下进行的正电子发射断层扫描分析显示，间歇性冷应激导致同侧区域的摄取显著增加，包括与突出网络相关的前扣带皮层和岛叶皮层以及与认知相关的海马。在与默认模式网络相关的后扣带皮层中观察到显著的减少。溶血磷脂酸受体1型敲除小鼠几乎消除了这些间歇性冷应激诱导的变化。研究结果表明，间歇性冷应激诱导的全身性疼痛反应是由与突出网络和认知相关的特定脑位点的溶血磷脂酸受体1型介导的，这可能会导致纤维肌痛治疗的进一步发展。
The intermittent cold stress‐induced generalized pain response mimics the pathophysiological and pharmacotherapeutic features reported for fibromyalgia patients, including the presence of chronic generalized pain and female dominance. In addition, the intermittent cold stress‐induced generalized pain is abolished in lysophosphatidic acid receptor type‐1 knockout mice, as reported in many cases of neuropathic pain models. This study aimed to identify the brain loci involved in the intermittent cold stress generalized pain response and test their dependence on the lysophosphatidic acid receptor type‐1. Positron emission tomography analyses using 2‐deoxy‐2‐[18F]fluoro‐d‐glucose in the presence of a pain stimulus showed that intermittent cold stress causes a significant increase in uptake in the ipsilateral regions, including the salience networking‐related anterior cingulate cortex and insular cortex and the cognition‐related hippocampus. A significant decrease was observed in the default mode network‐related posterior cingulate cortex. Almost these intermittent cold stress‐induced changes were abolished in lysophosphatidic acid receptor type‐1 knockout mice. There results suggest that the intermittent cold stress‐induced generalized pain response is mediated by the lysophosphatidic acid receptor type‐1 in specific brain loci related to salience networking and cognition, which may lead to further developments in the treatment of fibromyalgia.
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影响因子：
4.3
作者：
Ueda H;Dozono N;Tanaka K;Kaneko S;Neyama H;Uchida H
通讯作者：
Uchida H
DOI：
--
发表时间：
1995
期刊：
Revista clínica española (Ed. impresa)
影响因子：
--
作者：
F. J. Ballina García;P. Martín Lascuevas;A. Iglesias García;R. Hernández Mejía;A. Cueto Espinar
通讯作者：
A. Cueto Espinar
DOI：
--
发表时间：
2005
期刊：
影响因子：
--
作者：
Don Quijote
通讯作者：
Don Quijote
DOI：
10.1016/j.jpain.2017.02.437
发表时间：
2017-07
期刊：
The journal of pain
影响因子：
--
作者：
Schreiber KL;Loggia ML;Kim J;Cahalan CM;Napadow V;Edwards RR
通讯作者：
Edwards RR
影响因子：
3.1
作者：
Menon, Vinod;Uddin, Lucina Q.
通讯作者：
Uddin, Lucina Q.