Painful After-Sensations in Fibromyalgia are Linked to Catastrophizing and Differences in Brain Response in the Medial Temporal Lobe.
Painful After-Sensations in Fibromyalgia are Linked to Catastrophizing and Differences in Brain Response in the Medial Temporal Lobe.
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DOI：
10.1016/j.jpain.2017.02.437
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Edwards RR
中科院分区：
文献类型：
--
作者：
Schreiber KL;Loggia ML;Kim J;Cahalan CM;Napadow V;Edwards RR
纤维肌痛（FM）是一种复杂的综合征，其特征在于慢性广泛疼痛、痛觉过敏和其他致残症状。虽然FM患者对实验性疼痛的大脑反应一直是深入研究的对象，但疼痛后感觉（PAS）的生物学基础及其与负面情绪的关系却很少受到关注。在这项横断面队列研究中，通过暴露于腿部持续、中度疼痛的袖带刺激，评估FM受试者（n = 53）和健康对照受试者（n = 17）的PAS，单独校准至目标疼痛强度40/100。尽管需要较低的袖带压力来达到目标疼痛水平，FM患者在袖带刺激结束后15秒报告了更明显的PAS，这与临床疼痛评分呈正相关。功能磁共振成像显示减少失活的内侧颞叶（MTL;杏仁核，海马，海马旁回）FM患者，在疼痛刺激，以及在随后的poststimulation期间，当PAS的经验。此外，功能性磁共振成像信号测量在后刺激期间在MTL，以及在岛和前中扣带回和内侧前额叶皮质，与报告PAS的严重程度FM患者。这些结果表明，MTL在FM患者的PAS中起作用。PAS在FM中更常见和严重，并与临床疼痛和灾难化相关。PAS的严重程度也与MTL失活较少，这表明MTL，默认模式网络的核心节点，可能是重要的延长FM的疼痛感觉。
Fibromyalgia (FM) is a complex syndrome characterized by chronic widespread pain, hyperalgesia, and other disabling symptoms. Although the brain response to experimental pain in FM patients has been the object of intense investigation, the biological underpinnings of painful after-sensations (PAS), and their relation to negative affect have received little attention. In this cross-sectional cohort study, subjects with FM (n = 53) and healthy controls (n = 17) were assessed for PAS using exposure to a sustained, moderately painful cuff stimulus to the leg, individually calibrated to a target pain intensity of 40 of 100. Despite requiring lower cuff pressures to achieve the target pain level, FM patients reported more pronounced PAS 15 seconds after the end of cuff stimulation, which correlated positively with clinical pain scores. Functional magnetic resonance imaging revealed reduced deactivation of the medial temporal lobe (MTL; amygdala, hippocampus, parahippocampal gyrus) in FM patients, during pain stimulation, as well as in the ensuing poststimulation period, when PAS are experienced. Moreover, the functional magnetic resonance imaging signal measured during the poststimulation period in the MTL, as well as in the insular and anterior middle cingulate and medial prefrontal cortices, correlated with the severity of reported PAS by FM patients. These results suggest that the MTL plays a role in PAS in FM patients. PAS are more common and severe in FM, and are associated with clinical pain and catastrophizing. PAS severity is also associated with less MTL deactivation, suggesting that the MTL, a core node of the default mode network, may be important in the prolongation of pain sensation in FM.
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影响因子：
3.7
作者：
Baliki MN;Mansour AR;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
3.2
作者：
Albrecht DS;MacKie PJ;Kareken DA;Hutchins GD;Chumin EJ;Christian BT;Yoder KK
通讯作者：
Yoder KK
影响因子：
4.9
作者：
Campbell CM;McCauley L;Bounds SC;Mathur VA;Conn L;Simango M;Edwards RR;Fontaine KR
通讯作者：
Fontaine KR
DOI：
10.1523/jneurosci.1984-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Baliki MN;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
5.3
作者：
Baliki, Marwan N.;Chialvo, Dante R.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania