Saliency, switching, attention and control: a network model of insula function.
Saliency, switching, attention and control: a network model of insula function.
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DOI：
10.1007/s00429-010-0262-0
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发表时间：
2010-06
影响因子：
3.1
通讯作者：
Uddin, Lucina Q.
中科院分区：
文献类型：
--
作者：
Menon, Vinod;Uddin, Lucina Q.
关键词：
脑岛是一种大脑结构，涉及不同的认知、情感和调节功能，包括内感受性意识、情绪反应和共情过程。虽然传统上被视为边缘系统区域，但来自网络分析的最新证据表明，脑岛，尤其是其前部，在高级认知控制和注意力过程中起着关键作用。我们在此提出的关键见解和观点是，前脑岛是一个不可或缺的枢纽，在介导涉及对外界定向注意力和对内定向或自我相关认知的其他大规模大脑网络之间的动态相互作用中发挥作用。我们提出的模型假定脑岛对显著事件敏感，其核心功能是标记此类事件以便进行进一步处理，并启动适当的控制信号。前脑岛和前扣带皮层形成一个“显著网络”，其作用是区分内部和外部个人刺激中最相关的部分，以指导行为。在我们的网络模型框架内，归因于脑岛的不同功能可以通过一些基本机制来概念化：（1）自下而上地检测显著事件；（2）在检测到显著事件时在其他大规模网络之间进行切换，以促进对注意力和工作记忆资源的获取；（3）前脑岛和后脑岛相互作用，调节对显著刺激的自主神经反应；（4）与前扣带皮层的强功能耦合，促进对运动系统的快速访问。通过这种方式，以脑岛为其不可或缺的枢纽，显著网络协助目标大脑区域对显著刺激产生适当的行为反应。我们认为，这个框架为神经正常成年人的脑岛功能提供了一个简洁的解释，并可能为情感和社会认知障碍的神经基础提供新的见解。
The insula is a brain structure implicated in disparate cognitive, affective, and regulatory functions, including interoceptive awareness, emotional responses, and empathic processes. While classically considered a limbic region, recent evidence from network analysis suggests a critical role for the insula, particularly the anterior division, in high-level cognitive control and attentional processes. The crucial insight and view we present here is of the anterior insula as an integral hub in mediating dynamic interactions between other large-scale brain networks involved in externally oriented attention and internally oriented or self-related cognition. The model we present postulates that the insula is sensitive to salient events, and that its core function is to mark such events for additional processing and initiate appropriate control signals. The anterior insula and the anterior cingulate cortex form a “salience network” that functions to segregate the most relevant among internal and extrapersonal stimuli in order to guide behavior. Within the framework of our network model, the disparate functions ascribed to the insula can be conceptualized by a few basic mechanisms: (1) bottom–up detection of salient events, (2) switching between other large-scale networks to facilitate access to attention and working memory resources when a salient event is detected, (3) interaction of the anterior and posterior insula to modulate autonomic reactivity to salient stimuli, and (4) strong functional coupling with the anterior cingulate cortex that facilitates rapid access to the motor system. In this manner, with the insula as its integral hub, the salience network assists target brain regions in the generation of appropriate behavioral responses to salient stimuli. We suggest that this framework provides a parsimonious account of insula function in neurotypical adults, and may provide novel insights into the neural basis of disorders of affective and social cognition.
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影响因子：
2.5
作者：
Downar, J;Crawley, AP;Davis, KD
通讯作者：
Davis, KD
DOI：
10.1098/rstb.1996.0125
发表时间：
1996-10-29
影响因子：
6.3
作者：
Damasio, AR
通讯作者：
Damasio, AR
影响因子：
5.7
作者：
Cole, Michael W.;Schneider, Walter
通讯作者：
Schneider, Walter
影响因子：
3.2
作者：
Cabeza, R;Prince, SE;Rubin, DC
通讯作者：
Rubin, DC
影响因子：
2.5
作者：
Baird, A;Dewar, BK;Cipolotti, L
通讯作者：
Cipolotti, L