Pre- to post-diagnosis weight change and associations with physical functional limitations in breast cancer survivors.
Pre- to post-diagnosis weight change and associations with physical functional limitations in breast cancer survivors.
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DOI：
10.1007/s11764-014-0356-4
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Kroenke CH
中科院分区：
文献类型：
--
作者：
Young A;Weltzien E;Kwan M;Castillo A;Caan B;Kroenke CH
我们调查了一组乳腺癌幸存者诊断前后的体重变化和功能限制。一个由1,841名早期乳腺癌幸存者组成的队列提供了诊断前和诊断后平均2年的体重和身体功能信息。使用Wilcoxon检验比较每个BMI类别和每个体重变化类别的平均限制数量。采用逻辑回归分析确定诊断前1年至诊断后2年体重变化与功能受限之间的横断面相关性。与BMI<25 kg/m2的女性相比，BMI≥30 kg/m2的女性的身体限制显著更高（中度/重度限制为2.06 vs 0.96，轻度限制为3.92 vs 3.27，下半身限制为1.31 vs 0.47，所有其他限制为0.76 vs 0.49; P<0.0001）。报告体重大幅增加的女性（≥诊断前体重的10%）更有可能报告任何限制（OR=1.79; 95%置信区间（CI）=1.23-2.61），中度/重度限制（OR=2.30; 95% CI=1.75-3.02）和较低的身体限制（OR=2.05; 95% CI=1.53-2.76）。然而，体重减轻和功能限制之间的关联取决于诊断前BMI和合并症状态。在无合并症的女性中，正常体重女性的体重大幅减轻（≥诊断前体重的10%）与功能限制的风险较高相关，而在超重/肥胖女性中，体重大幅减轻似乎与限制的风险较低相关。在合并症的女性中，超重/肥胖女性的中度体重减轻与中度/重度身体限制的风险较高相关。体重大幅增加与身体功能受限的风险较高相关，但体重减轻与功能受限之间的相关性可能取决于初始BMI和合并症状态。在这项研究中，我们发现乳腺癌幸存者的体重减轻和体重增加与身体功能限制的风险较高有关。因此，体重维持可能是预防和/或降低乳腺癌幸存者功能下降风险的重要因素。
We investigated pre- to post-diagnosis weight change and functional limitations in a cohort of breast cancer survivors. A cohort of 1,841 early-stage breast cancer survivors provided information on pre- and post-diagnosis weight and physical function on average 2 years post-diagnosis. The mean number of limitations for each BMI category and each weight change category were compared using the Wilcoxon test. Cross-sectional associations between weight change, from 1 year prior to diagnosis to 2 years post-diagnosis, and functional limitations were determined using logistic regression. Women with BMI≥30 kg/m2 had significantly higher physical limitations compared to women with BMI<25 kg/m2 (2.06 vs 0.96 for moderate/severe limitations, 3.92 vs 3.27 for mild limitations, 1.31 vs 0.47 for lower body limitations, and 0.76 vs 0.49 for all other limitations; P<0.0001). Women who reported a large weight gain (≥10 % of pre-diagnosis weight) were more likely to report any limitation (OR=1.79; 95 % confidence interval (CI)=1.23–2.61), a moderate/severe limitation (OR=2.30; 95 % CI=1.75–3.02), and a lower body limitation (OR=2.05; 95 % CI=1.53–2.76) compared to women who maintained weight within 5 % of pre-diagnosis weight. However, associations between weight loss and functional limitations depended on pre-diagnosis BMI and comorbidity status. Among women without comorbidity, large weight loss (≥10 % of pre-diagnosis weight) in normal-weight women was associated with higher risk of functional limitations, whereas among overweight/obese women, large weight loss appeared to be associated with a lower risk of limitations. Among women with comorbidity, moderate weight loss in overweight/obese women was associated with a higher risk of a moderate/severe physical limitation. Large weight gain was associated with a higher risk of physical functional limitations, but associations between weight loss and functional limitations may depend on initial BMI and comorbidity status. In this study we found that both weight loss and weight gain among breast cancer survivors were associated with a higher risk of physical functional limitations. Weight maintenance, therefore, may be an important factor in preventing and/or reducing the risk of functional decline in breast cancer survivors.
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DOI：
10.1093/gerona/57.1.m19
发表时间：
2002-01-01
影响因子：
5.1
作者：
Chen, HL;Bermúdez, OI;Tucker, KL
通讯作者：
Tucker, KL
DOI：
10.1093/geronj/21.4.556
发表时间：
1966-01-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
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通讯作者：
BRESLAU, N
DOI：
10.1093/gerona/glp042
发表时间：
2010-01-01
影响因子：
5.1
作者：
Lee, Jung Sun;Visser, Marjolein;Newman, Anne B.
通讯作者：
Newman, Anne B.
影响因子：
5
作者：
Sternfeld, B;Ngo, L;Tager, IB
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影响因子：
45.3
作者：
Antoun, Sami;Birdsell, Laura;Baracos, Vickie E.
通讯作者：
Baracos, Vickie E.