Population-scale organization of cerebellar granule neuron signaling during a visuomotor behavior.
Population-scale organization of cerebellar granule neuron signaling during a visuomotor behavior.
复制标题
DOI：
10.1038/s41598-017-15938-w
复制
发表时间：
2017-11-24
影响因子：
4.6
通讯作者：
Aksay ERF
中科院分区：
文献类型：
--
作者：
Sylvester SJG;Lee MM;Ramirez AD;Lim S;Goldman MS;Aksay ERF
小脑输入层的颗粒细胞构成了人脑中超过一半的神经元，被认为是学习的关键。然而，很少有人知道颗粒神经元信号在人口规模的行为。我们在清醒的斑马鱼视动行为过程中使用钙成像来记录整个小脑群体中转基因识别的颗粒神经元。在任何给定时间，人群中的很大一部分都有反应。相反，核心小脑前区的人口，颗粒神经元的反应是相对异质性的，与整流程度的变化和积极与消极的活动变化的平衡。附近细胞的功能相关性最强，矫正程度和平均反应信号的空间梯度较弱。这些数据为小脑功能打开了一扇新的窗口，并表明颗粒层信号代表了核心感觉运动通路中代表不足的基本构建模块，从而能够构建新的学习活动模式。
Granule cells at the input layer of the cerebellum comprise over half the neurons in the human brain and are thought to be critical for learning. However, little is known about granule neuron signaling at the population scale during behavior. We used calcium imaging in awake zebrafish during optokinetic behavior to record transgenically identified granule neurons throughout a cerebellar population. A significant fraction of the population was responsive at any given time. In contrast to core precerebellar populations, granule neuron responses were relatively heterogeneous, with variation in the degree of rectification and the balance of positive versus negative changes in activity. Functional correlations were strongest for nearby cells, with weak spatial gradients in the degree of rectification and the average sign of response. These data open a new window upon cerebellar function and suggest granule layer signals represent elementary building blocks under-represented in core sensorimotor pathways, thereby enabling the construction of novel patterns of activity for learning.
登录
查看更多内容
影响因子：
4.8
作者：
Brondi M;Sato SS;Rossi LF;Ferrara S;Ratto GM
通讯作者：
Ratto GM
影响因子：
16.2
作者：
Borges-Merjane, Carolina;Trussell, Laurence O.
通讯作者：
Trussell, Laurence O.
影响因子：
16.2
作者：
Daie, Kayvon;Goldman, Mark S.;Aksay, Emre R. F.
通讯作者：
Aksay, Emre R. F.
影响因子：
2.5
作者：
Aksay, E;Baker, R;Tank, DW
通讯作者：
Tank, DW
影响因子：
64.8
作者：
Chadderton, P;Margrie, TW;Häusser, M
通讯作者：
Häusser, M