Wanted, dead or alive: new viral vaccines.
Wanted, dead or alive: new viral vaccines.
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DOI：
10.1016/j.antiviral.2009.08.008
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发表时间：
2009-11
影响因子：
7.6
通讯作者：
Slifka, Mark K.
中科院分区：
文献类型：
--
作者：
Amanna, Ian J.;Slifka, Mark K.
疫苗接种是保护公众免受传染病侵害的最有效方法之一。疫苗可分为两大类：复制疫苗（即活疫苗、减毒疫苗）和非复制疫苗（例如灭活疫苗或亚单位疫苗）。人们认为减毒活疫苗在抗病毒免疫反应的质量、保护性免疫水平和保护性免疫持续时间方面优于非复制疫苗。尽管这是该领域内的普遍观点，但该规则也有一些例外。在这里，我们将探讨其中一些结论所依据的历史文献，包括“自然实验”，并描述复制疫苗与非复制疫苗相比的功效示例。通过更好地了解疫苗如何成功发挥作用，我们希望开发出更好的“下一代”疫苗以及针对艾滋病毒的新疫苗。艾滋病毒是一种具有全球重要性的病原体，目前还没有获得许可的疫苗。
Vaccination is one of the most effective methods used for protecting the public against infectious disease. Vaccines can be segregated into two general categories; replicating vaccines (i.e., live, attenuated vaccines) and non-replicating vaccines (e.g., inactivated or subunit vaccines). It has been assumed that live attenuated vaccines are superior to non-replicating vaccines in terms of the quality of the antiviral immune response, the level of protective immunity, and the duration of protective immunity. Although this a prevalent viewpoint within the field, there are several exceptions to the rule. Here, we will explore the historical literature in which some of these conclusions have been based, including “Experiments of Nature” and describe examples of the efficacy of replicating vaccines compared to their non-replicating counterparts. By building a better understanding of how successful vaccines work, we hope to develop better “next-generation” vaccines as well as new vaccines against HIV – a pathogen of global importance for which no licensed vaccine currently exists.
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影响因子：
--
作者：
BOTTIGER, M
通讯作者：
BOTTIGER, M
影响因子：
3.7
作者：
Co, MDT;Terajima, M;Rothman, AL
通讯作者：
Rothman, AL
影响因子：
168.9
作者：
Buchbinder, Susan P.;Mehrotra, Devon V.;Duerr, Ann;Fitzgerald, Daniel W.;Mogg, Robin;Li, David;Gilbert, Peter B.;Lama, Javier R.;Marmor, Michael;del Rio, Carlos;McElrath, M. Juliana;Casimiro, Danilo R.;Gottesdiener, Keith M.;Chodakewitz, Jeffrey A.;Corey, Lawrence;Robertson, Michael N.
通讯作者：
Robertson, Michael N.
影响因子：
7.7
作者：
Böttiger, M;Gustavsson, E;Svensson, Å
通讯作者：
Svensson, Å
DOI：
10.1073/pnas.1233578100
发表时间：
2003-08-05
影响因子：
11.1
作者：
Belyakov, IM;Earl, P;Berzofsky, JA
通讯作者：
Berzofsky, JA