Dewormer drug fenbendazole has antiviral effects on BoHV-1 productive infection in cell cultures.
Dewormer drug fenbendazole has antiviral effects on BoHV-1 productive infection in cell cultures.
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驱虫药芬苯达唑对细胞培养物中 BoHV-1 产生性感染具有抗病毒作用
DOI：
10.4142/jvs.2020.21.e72
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发表时间：
2020-09
影响因子：
1.8
通讯作者：
Zhu L
中科院分区：
文献类型：
--
作者：
Chang L;Zhu L
Background Fenbendazole, a dewormer drug, is used widely in the clinical treatment of parasite infections in animals. Recent studies have shown that fenbendazole has substantial effects on tumor growth, immune responses, and inflammatory responses, suggesting that fenbendazole is a pluripotent drug. Nevertheless, the antiviral effects have not been reported. Fenbendazole can disrupt microtubules, which are essential for multiple viruses infections, suggesting that fenbendazole might have antiviral effects. Objectives This study examined whether fenbendazole could inhibit bovine herpesvirus 1 (BoHV-1) productive infection in cell cultures. Methods The effects of fenbendazole on viral production, transcription of the immediate early (IE) genes, viron-associated protein expression, and the cellular signaling PLC-γ1/Akt pathway were assessed using distinct methods. Results Fenbendazole could inhibit BoHV-1 productive infections significantly in MDBK cells in a dose-dependent manner. A time-of-addition assay indicated that fenbendazole affected both the early and late stages in the virus replication cycles. The transcription of IE genes, including BoHV-1 infected cell protein 0 (bICP0), bICP4, and bICP22, as well as the synthesis of viron-associated proteins, were disrupted differentially by the fenbendazole treatment. The treatment did not affect the cellular signaling pathway of PLC-γ1/Akt, a known cascade playing important roles in virus infection. Conclusions Overall, fenbendazole has antiviral effects on BoHV-1 replication.
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影响因子：
7.2
作者：
Fiorito, Filomena;Marfe, Gabriella;Pagnini, Ugo
通讯作者：
Pagnini, Ugo
影响因子：
3.8
作者：
Sanderson, CM;Hollinshead, M;Smith, GL
通讯作者：
Smith, GL
影响因子：
4.6
作者：
Dogra N;Kumar A;Mukhopadhyay T
通讯作者：
Mukhopadhyay T
影响因子：
3.7
作者：
Nehete PN;Wilkerson G;Nehete BP;Chitta S;Ruiz JC;Scholtzova H;Williams LE;Abee CR;Vanchiere JA
通讯作者：
Vanchiere JA
影响因子：
5.4
作者：
Kotsakis, A;Pomeranz, LE;Blaho, JA
通讯作者：
Blaho, JA