Pruritus in neuromyelitis optica spectrum disorders and multiple sclerosis
Pruritus in neuromyelitis optica spectrum disorders and multiple sclerosis
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视神经脊髓炎谱系疾病和多发性硬化症中的瘙痒
DOI：
10.1016/j.jocn.2020.07.022
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Shengyuan Yu
中科院分区：
文献类型：
--
作者：
Mianwang He;Lei Wu;Dehui Huang;Vicky Yau;Shengyuan Yu
目的视神经肌萎缩性疾病（NMOSD）与多发性硬化（MS）的早期鉴别诊断目前仍是一个难题。瘙痒被报告为NMOSD伴血清水通道蛋白-4免疫球蛋白G抗体（AQP 4-IgG）的常见或特异性特征。我们的目的是验证瘙痒是否可以帮助区分NMOSD和MS。方法我们回顾性分析了NMOSD和MS患者的连续病例的医疗记录，人口统计学数据，临床特征，是否有瘙痒，结果NMOSD组21.0%（22/105），NMOSD组2.1%（2/96），的MS患者在病程中报告瘙痒（p < 0.01）。20.5%（18/88）的AQP 4-IgG阳性和23.5%（4/17）的AQP 4-IgG阴性NMOSD患者在病程期间报告瘙痒（p = 0.775）。12.4%（13/105）的NMOSD和1.0%（1/96）的MS患者在疾病首次发作时报告瘙痒（p < 0.01）。20.0%（21/105）的NMOSD患者和1.0%（1/96）的MS患者在第一次和第二次发病时出现瘙痒（P < 0.01）。瘙痒在NMOSD中比MS更常见，这可能有助于区分NMOSD和MS，特别是在早期阶段。
PurposeDifferential diagnosis between neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) at early stage remains challenging at present. Pruritus is reported as a common or specific feature in NMOSD with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). We aim to verify whether pruritus can help in distinguishing NMOSD from MS.MethodsWe retrospectively reviewed the medical records of consecutive cases of NMOSD and MS patients, demographic data, clinical features, whether or not had pruritus, serum AQP4-IgG status and magnetic resonance imaging (MRI) results.Results21.0% (22/105) of NMOSD patients and 2.1% (2/96) of MS patients reported pruritus during disease course (p < 0.01). 20.5% (18/88) of AQP4-IgG positive and 23.5% (4/17) of AQP4-IgG negative NMOSD patients reported pruritus during disease course (p = 0.775). 12.4% (13/105) of NMOSD and 1.0% (1/96) of MS patients reported pruritus at the first attack episode of disease (p < 0.01). 20.0% (21/105) of NMOSD and 1.0% (1/96) of MS patients reported pruritus at the first and second attack episodes of disease (p < 0.01).ConclusionPruritus is a common and relatively specific feature in either AQP4-IgG positive or negative NMOSD. Pruritus occurs more frequently in NMOSD than MS, which may help in distinguishing NMOSD from MS, especially at early stage.
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影响因子：
9.9
作者：
Wingerchuk DM;Banwell B;Bennett JL;Cabre P;Carroll W;Chitnis T;de Seze J;Fujihara K;Greenberg B;Jacob A;Jarius S;Lana-Peixoto M;Levy M;Simon JH;Tenembaum S;Traboulsee AL;Waters P;Wellik KE;Weinshenker BG;International Panel for NMO Diagnosis
通讯作者：
International Panel for NMO Diagnosis
影响因子：
2.5
作者：
Davidson, Steve;Zhang, Xijing;Giesler, Glenn J., Jr.
通讯作者：
Giesler, Glenn J., Jr.
影响因子：
7.4
作者：
Akiyama T;Nguyen T;Curtis E;Nishida K;Devireddy J;Delahanty J;Carstens MI;Carstens E
通讯作者：
Carstens E
影响因子：
9.9
作者：
Wingerchuk, D. M.;Lennon, V. A.;Weinshenker, B. G.
通讯作者：
Weinshenker, B. G.
影响因子：
48
作者：
Thompson, Alan J.;Banwell, Brenda L.;Cohen, Jeffrey A.
通讯作者：
Cohen, Jeffrey A.