Low serum bilirubin level predicts the development of chronic kidney disease in patients with type 2 diabetes mellitus.
Low serum bilirubin level predicts the development of chronic kidney disease in patients with type 2 diabetes mellitus.
复制标题
DOI：
10.3904/kjim.2015.153
复制
发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Kim YK
中科院分区：
文献类型：
--
作者：
Ahn KH;Kim SS;Kim WJ;Kim JH;Nam YJ;Park SB;Jeon YK;Kim BH;Kim IJ;Kim YK
我们评估了血清胆红素水平是否可以预测2型糖尿病（T2 DM）患者慢性肾病（CKD）的发展。这是一项对釜山国立大学医院患者的回顾性观察性纵向研究。共入组了349例肾功能正常（估计肾小球滤过率≥ 60 mL/min/1.73 m2）的T2 DM患者。主要结局是CKD 3期或以上的发展。根据基线时血清总胆红素水平的四分位数将患者分为四组。总血清胆红素水平范围最低的组（Q1）显示CKD 3期或以上的累积发生率最高，高于其他下四分位数（Q1 vs. Q4;风险比[HR]，6.75; 95%置信区间[CI]，1.54 - 29.47; p = 0.011）。在多变量分析中，血清胆红素水平第二低四分位数发生CKD 3期或以上的风险高于血清胆红素水平最高四分位数（Q2 vs. Q4; HR，9.36; 95% CI，1.33 - 65.73; p = 0.024）。在正常白蛋白尿亚组（n = 236）中，多变量分析显示，血清胆红素水平最低四分位数发生CKD 3期或以上的风险高于血清胆红素水平最高四分位数（Q1 vs. Q4; HR，7.36; 95% CI，1.24 - 35.82; p = 0.019）。血清胆红素可能是预测肾功能正常的2型糖尿病患者CKD进展的早期临床指标。
We evaluated whether serum bilirubin levels can predict the development of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM). This was a retrospective observational longitudinal study of patients presenting at the Pusan National University Hospital. A total of 349 patients with T2DM and preserved kidney function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m2) were enrolled. The main outcome was the development of CKD stage 3 or greater. The patients were divided into four groups according to the quartiles of the total serum bilirubin levels at baseline. The group with the lowest range of total serum bilirubin level (Q1) showed the highest cumulative incidence of CKD stage 3 or greater than that of the other lower quartiles (Q1 vs. Q4; hazard ratio [HR], 6.75; 95% confidence interval [CI], 1.54 to 29.47; p = 0.011). In multivariate analysis, the risk of developing CKD stage 3 or greater was higher in the second lowest quartile of the serum bilirubin level than that in the highest quartile of the serum bilirubin level (Q2 vs. Q4; HR, 9.36; 95% CI, 1.33 to 65.73; p = 0.024). In the normoalbuminuria subgroup (n = 236), multivariate analysis showed that the risk of developing CKD stage 3 or greater was higher in the lowest quartile of the serum bilirubin level than that in the highest quartile of the serum bilirubin level (Q1 vs. Q4; HR, 7.36; 95% CI, 1.24 to 35.82; p = 0.019). Serum bilirubin might be an early clinical marker for predicting the progression of CKD in patients with T2DM and preserved renal function.
登录
查看更多内容
影响因子：
7.7
作者：
Okada, S;Shikata, K;Makino, H
通讯作者：
Makino, H
影响因子：
158.5
作者：
Lewis, EJ;Hunsicker, LG;Raz, I
通讯作者：
Raz, I
DOI：
10.1016/j.bbrc.2009.06.029
发表时间：
2009-08-21
影响因子：
3.1
作者：
Mazzone, Graciela Lujan;Rigato, Igino;Tiribelli, Claudio
通讯作者：
Tiribelli, Claudio
影响因子：
3.2
作者：
Toya K;Babazono T;Hanai K;Uchigata Y
通讯作者：
Uchigata Y
韩国糖尿病性肾病的患病率和决定因素：韩国国家健康和营养检查调查。
影响因子：
5.9
作者：
Ahn JH;Yu JH;Ko SH;Kwon HS;Kim DJ;Kim JH;Kim CS;Song KH;Won JC;Lim S;Choi SH;Han K;Cha BY;Kim NH;Taskforce Team of Diabetes Fact Sheet of the Korean Diabetes Association
通讯作者：
Taskforce Team of Diabetes Fact Sheet of the Korean Diabetes Association