Behavioral impairment produced by low-level postnatal PCB exposure in monkeys.
Behavioral impairment produced by low-level postnatal PCB exposure in monkeys.
复制标题
猴子出生后低水平 PCB 暴露造成的行为障碍。
DOI：
10.1006/enrs.1998.3917
复制
发表时间：
1999
影响因子：
8.3
通讯作者：
Deborah C. Rice
中科院分区：
文献类型：
--
作者：
Deborah C. Rice
尽管最近的一项研究报告说，婴儿期的心理健康评分较低与母乳中的多氯联苯浓度有关，但绝大多数人类证据表明，多氯联苯（PCB）诱导的行为缺陷是由于产前接触而不是通过母乳接触所致。在目前的研究中，猴子从出生到20周龄都服用了代表人类母乳中发现的多氯联苯的多氯联苯同系物混合物。在给药期结束时，接触多氯联苯的猴子的血液和脂肪水平在一般人群中观察到的范围内，而对照猴子的水平低于工业化国家人类中观察到的平均水平。当猴子年龄在2.5至5.0岁之间时，对一系列任务进行行为评估。鲁棒赤字观察空间延迟交替，固定的时间间隔，和差异强化低速率性能。在一系列非空间和空间辨别反转任务中，没有观察到组间差异。行为缺陷包括学习迟缓、持续行为和无法抑制不适当的反应。这些结果的影响，通过母乳暴露于多氯联苯的行为障碍的潜在贡献。
The preponderance of evidence in humans suggests that polychlorinated biphenyl (PCB)-induced behavioral deficits result from prenatal exposure rather than exposure through breast milk, although a recent study reported lower psychomotor scores during infancy associated with PCB concentration in breast milk. In the current study, monkeys were dosed from birth to 20 weeks of age with a PCB congener mixture representative of the PCBs found in human breast milk. Blood and fat levels of PCB-exposed monkeys at the end of the dosing period were within the range observed in the general human population, while levels in control monkeys were below averages observed in humans in industrialized countries. Behavioral assessment on a series of tasks was performed when monkeys were between 2.5 and 5.0 years of age. Robust deficits were observed on spatial delayed alternation, fixed interval, and differential reinforcement of low rate performance. No group differences were observed for the number of errors on a series of nonspatial and spatial discrimination reversal tasks. Behavioral deficits included retarded learning, perseverative behavior, and inability to inhibit inappropriate responding. These results have implications for the potential contribution of exposure to PCBs through breast milk to behavioral impairment.
猴子围产期 PCB 暴露导致延迟空间交替缺陷。
影响因子：
6.1
作者：
Levin,ED;Schantz,SL;Bowman,RE
通讯作者：
Bowman,RE
妊娠期和哺乳期接触 TCDD 或共面 PCB 对空间学习的影响。
影响因子：
2.9
作者：
Schantz,SL;Seo,BW;Moshtaghian,J;Peterson,RE;Moore,RW
通讯作者：
Moore,RW
影响因子：
2.9
作者：
JACOBSON, JL;JACOBSON, SW;HUMPHREY, HEB
通讯作者：
HUMPHREY, HEB