Population genomics of post-glacial western Eurasia.
Population genomics of post-glacial western Eurasia.
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DOI：
10.1038/s41586-023-06865-0
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发表时间：
2024-01
期刊：
影响因子：
64.8
通讯作者：
Willerslev, Eske
中科院分区：
文献类型：
--
作者：
Allentoft, Morten E.;Sikora, Martin;Refoyo-Martinez, Alba;Irving-Pease, Evan K.;Fischer, Anders;Barrie, William;Ingason, Andres;Stenderup, Jesper;Sjoegren, Karl-Goeran;Pearson, Alice;Sousa da Mota, Barbara;Schulz Paulsson, Bettina;Halgren, Alma;Macleod, Ruairidh;Jorkov, Marie Louise Schjellerup;Demeter, Fabrice;Sorensen, Lasse;Nielsen, Poul Otto;Henriksen, Rasmus A.;Vimala, Tharsika;Mccoll, Hugh;Margaryan, Ashot;Ilardo, Melissa;Vaughn, Andrew;Fischer Mortensen, Morten;Nielsen, Anne Birgitte;Ulfeldt Hede, Mikkel;Johannsen, Niels Norkjaer;Rasmussen, Peter;Vinner, Lasse;Renaud, Gabriel;Stern, Aaron;Jensen, Theis Zetner Trolle;Scorrano, Gabriele;Schroeder, Hannes;Lysdahl, Per;Ramsoe, Abigail Daisy;Skorobogatov, Andrei;Schork, Andrew Joseph;Rosengren, Anders;Ruter, Anthony;Outram, Alan;Timoshenko, Aleksey A.;Buzhilova, Alexandra;Coppa, Alfredo;Zubova, Alisa;Silva, Ana Maria;Hansen, Anders J.;Gromov, Andrey;Logvin, Andrey;Gotfredsen, Anne Birgitte;Henning Nielsen, Bjarne;Gonzalez-Rabanal, Borja;Lalueza-Fox, Carles;Mckenzie, Catriona J.;Gaunitz, Charleen;Blasco, Concepcion;Liesau, Corina;Martinez-Labarga, Cristina;Pozdnyakov, Dmitri V.;Cuenca-Solana, David;Lordkipanidze, David O.;En'shin, Dmitri;Salazar-Garcia, Domingo C.;Price, T. Douglas;Boric, Dusan;Kostyleva, Elena;Veselovskaya, Elizaveta V.;Usmanova, Emma R.;Cappellini, Enrico;Brinch Petersen, Erik;Kannegaard, Esben;Radina, Francesca;Eylem Yediay, Fulya;Duday, Henri;Gutierrez-Zugasti, Igor;Merts, Ilya;Potekhina, Inna;Shevnina, Irina;Altinkaya, Isin;Guilaine, Jean;Hansen, Jesper;Aura Tortosa, Joan Emili;Zilhao, Joao;Vega, Jorge;Buck Pedersen, Kristoffer;Tunia, Krzysztof;Zhao, Lei;Mylnikova, Liudmila N.;Larsson, Lars;Metz, Laure;Yepiskoposyan, Levon;Pedersen, Lisbeth;Sarti, Lucia;Orlando, Ludovic;Slimak, Ludovic;Klassen, Lutz;Blank, Malou;Gonzalez-Morales, Manuel;Silvestrini, Mara;Vretemark, Maria;Nesterova, Marina S.;Rykun, Marina;Rolfo, Mario Federico;Szmyt, Marzena;Przybyla, Marcin;Calattini, Mauro;Sablin, Mikhail;Dobisikova, Miluse;Meldgaard, Morten;Johansen, Morten;Berezina, Natalia;Card, Nick;Saveliev, Nikolai A.;Poshekhonova, Olga;Rickards, Olga;Lozovskaya, Olga V.;Gabor, Oliver;Uldum, Otto Christian;Aurino, Paola;Kosintsev, Pavel;Courtaud, Patrice;Rios, Patricia;Mortensen, Peder;Lotz, Per;Persson, Per;Bangsgaard, Pernille;de Barros Damgaard, Peter;Vang Petersen, Peter;Martinez, Pilar Prieto;Wlodarczak, Piotr;Smolyaninov, Roman V.;Maring, Rikke;Menduina, Roberto;Badalyan, Ruben;Iversen, Rune;Turin, Ruslan;Vasilyev, Sergey;Wahlin, Sidsel;Borutskaya, Svetlana;Skochina, Svetlana;Sorensen, Soren Anker;Andersen, Soren H.;Jorgensen, Thomas;Serikov, Yuri B.;Molodin, Vyacheslav I.;Smrcka, Vaclav;Merts, Victor;Appadurai, Vivek;Moiseyev, Vyacheslav;Magnusson, Yvonne;Kjaer, Kurt H.;Lynnerup, Niels;Lawson, Daniel J.;Sudmant, Peter H.;Rasmussen, Simon;Korneliussen, Thorfinn Sand;Durbin, Richard;Nielsen, Rasmus;Delaneau, Olivier;Werge, Thomas;Racimo, Fernando;Kristiansen, Kristian;Willerslev, Eske
在全新世，欧亚大陆西部见证了几次大规模的人类迁徙。在这里，为了研究这些迁移的跨大陆影响，我们对来自欧亚大陆北方和西部的317个基因组进行了鸟枪测序，这些基因组主要来自中石器时代和新石器时代。这些数据与已发表的数据一起估算，以获得来自1,600多名古代人类的二倍体基因型。我们的分析揭示了从黑海到波罗的海的“大鸿沟”基因组边界。中石器时代的狩猎采集者在这一地带的东部和西部具有高度的遗传差异，新石器化的影响也同样不同。随着农业的引入，西部发生了大规模的祖先迁移，包括在许多地区几乎完全取代狩猎采集者，而在同一时期，该地区东部没有发生实质性的祖先迁移。同样，从新石器时代过渡期开始，西部的亲缘关系下降，而乌拉尔山脉以东的亲缘关系一直保持在4,000 bp左右，这与当地狩猎采集者群体的持续存在相一致。当Yamnaya相关的祖先在欧亚大陆西部传播约5，000 bp时，边界消失了，导致了第二次大规模的流动，在1，000年的时间内到达了欧洲的大部分地区。Yamnaya的遗传起源和命运仍然难以捉摸，但我们表明，来自中顿河地区的狩猎采集者为他们贡献了祖先。Yamnaya群体后来与球状双耳瓶文化相关的个体混合，然后扩展到欧洲。类似的失误发生在西伯利亚西部，在那里，我们报告了新的基因组数据，从“新石器时代草原”跨越西伯利亚森林草原到贝加尔湖。这些史前迁徙对欧亚人群的遗传多样性产生了深远而持久的影响。一项涉及欧亚大陆300多个古代基因组的鸟枪测序分析揭示了从黑海到波罗的海的东西遗传鸿沟，并提供了对新石器时代过渡对这一边界两侧的独特影响的见解。
Western Eurasia witnessed several large-scale human migrations during the Holocene. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 bp, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 bp, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a ‘Neolithic steppe’ cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations. An analysis involving the shotgun sequencing of more than 300 ancient genomes from Eurasia reveals a deep east–west genetic divide from the Black Sea to the Baltic, and provides insight into the distinct effects of the Neolithic transition on either side of this boundary.
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EPA-NG：遗传序列的大量平行进化位置。
影响因子：
6.5
作者：
Barbera P;Kozlov AM;Czech L;Morel B;Darriba D;Flouri T;Stamatakis A
通讯作者：
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影响因子：
9.8
作者：
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通讯作者：
Browning, Brian L.
影响因子：
64.8
作者：
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通讯作者：
Reich D
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
64.8
作者：
Damgaard, Peter de Barros;Marchi, Nina;Willerslev, Eske
通讯作者：
Willerslev, Eske