Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials.
Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials.
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作者：
Sun X;Siri S;Hurst A;Qiu H
小热休克蛋白 22 (HSP22) 属于热休克蛋白超家族，主要在心脏、大脑、骨骼肌和不同类型的癌症中表达。研究发现HSP22参与心肌细胞的不同细胞功能，在不同应激下的心脏保护中发挥重要作用，防止心肌细胞损伤。本文总结了 HSP22 在心脏中的多种功能及其通过调节基因转录、翻译后修饰、其相互作用蛋白的亚细胞易位和蛋白质降解、促进线粒体功能、心脏代谢、自噬、ROS 产生和抗凋亡作用的潜在分子机制。我们还讨论了 HSP22 与心脏病的关系，包括人类扩张型心肌病、压力超负荷引起的心力衰竭、缺血性心脏病和衰老相关的心脏代谢紊乱。收集到的信息将有助于深入了解 HSP22 在心脏病中的作用，并有助于发现治疗靶点。
Small heat shock protein 22 (HSP22) belongs to the superfamily of heat shock proteins and is predominantly expressed in the heart, brain, skeletal muscle, and different types of cancers. It has been found that HSP22 is involved in variant cellular functions in cardiomyocytes and plays a vital role in cardiac protection against cardiomyocyte injury under diverse stress. This review summarizes the multiple functions of HSP22 in the heart and the underlying molecular mechanisms through modulating gene transcription, post-translational modification, subcellular translocation of its interacting proteins, and protein degradation, facilitating mitochondrial function, cardiac metabolism, autophagy, and ROS production and antiapoptotic effect. We also discuss the association of HSP22 in cardiac pathologies, including human dilated cardiomyopathy, pressure overload-induced heart failure, ischemic heart diseases, and aging-related cardiac metabolism disorder. The collected information would provide insights into the understanding of the HSP22 in heart diseases and lead to discovering the therapeutic targets.
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影响因子：
37.8
作者：
CODD, MB;SUGRUE, DD;MELTON, LJ
通讯作者：
MELTON, LJ
DOI：
10.1016/s0167-4781(01)00237-8
发表时间：
2001-07-30
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
影响因子：
--
作者：
Kappé, G;Verschuure, P;De Jong, WW
通讯作者：
De Jong, WW
DOI：
10.1073/pnas.171297498
发表时间：
2001-07-31
影响因子：
11.1
作者：
Depre, C;Tomlinson, JE;Vatner, SF
通讯作者：
Vatner, SF
DOI：
10.1152/ajpheart.2001.280.1.h455
发表时间：
2001-01-01
影响因子：
4.8
作者：
Knowlton, AA;Sun, LM
通讯作者：
Sun, LM
影响因子：
39.3
作者：
Elliott, Perry;Andersson, Bert;Keren, Andre
通讯作者：
Keren, Andre