Marital status and survival in epithelial ovarian cancer patients: a SEER-based study.
Marital status and survival in epithelial ovarian cancer patients: a SEER-based study.
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上皮性卵巢癌患者的婚姻状况和生存率：一项基于 SEER 的研究
DOI：
10.18632/oncotarget.21648
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发表时间：
2017-10-24
期刊：
影响因子：
--
通讯作者：
Liu M
中科院分区：
文献类型：
--
作者：
Wang X;Li X;Su S;Liu M
婚姻状况已被证明与各种癌症患者的生存相关，但在卵巢上皮性癌（EOC）的大部分女性人群中除外。在这项研究中，我们回顾性地从2004年至2012年期间的监测、流行病学和最终结果（SEER）数据库中提取了10905例符合条件的EOC患者。我们将婚姻状况分为已婚、离婚/分居、丧偶和未婚。婚姻状况与其他变项之关联性以卡方检定进行分析。采用Kaplan-Meier检验比较各组生存曲线。采用多变量考克斯回归分析来评估婚姻状况对总生存率（OS）和上皮性卵巢癌特异性生存率（EOCSS）的影响。为了探讨婚姻状况如何影响同期诊断的患者，我们进一步根据TNM分期进行亚组分析。结果表明，婚姻状况是OS和EOCSS的独立预测因子。亚组分析表明，婚姻状况与预后的关系因病情不同而不同。在大多数情况下，丧偶患者的预后比其他组差，而从未结婚的患者与已婚患者的死亡风险相似。
Marital status has been proved to be correlated to the survival of patients in various cancer types, except for that in the large female population of epithelial ovarian cancer (EOC). In this study, we retrospectively extracted 10905 eligible EOC patients from the Surveillance, Epidemiology, and End Results (SEER) database in the period from 2004 to 2012. We categorized marital status as married, divorced/separated, widowed, and never married. Chi-square test was used to investigate the association between marital status and other variables. The Kaplan-Meier test was adopted to compare survival curves of different groups. Multivariate Cox regression analyses were conducted to estimate the effect of marital status on overall survival (OS) and epithelial ovarian cancer-specific survival (EOCSS). To explore how marital status affected patients diagnosed at the same stage, we further performed subgroup analyses according to TNM stage. The results showed that marital status was an independent predictor for OS and EOCSS. Subgroup analyses indicated that the relationship between marital status and prognosis varied according to different conditions. Widowed patients had poorer prognosis than the other groups in most conditions, while the never married group showed similar risk of mortality as the married ones.
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