Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality in older community-dwelling adults.
Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality in older community-dwelling adults.
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DOI：
10.1038/ejcn.2009.140
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发表时间：
2010-02
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
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作者：
维生素D缺乏与心血管疾病、骨质疏松症、肌肉力量差、福尔斯、骨折和死亡率有关。虽然老年人维生素D缺乏的风险很高，但血清25（OH）D与全因和心血管疾病死亡率的关系尚未在老年人中得到很好的表征。我们假设低血清25（OH）D预测老年人的死亡率。在1006名参加InCHIANTI研究的≥65岁成人中检查了血清25（OH）D和全因和心血管疾病死亡率，InCHIANTI研究是一项在意大利托斯卡纳进行的基于人群的前瞻性队列研究。在1998-1999年入组时测量血清25（OH）D，并随访参与者的死亡率。在6.5年的随访中，228名（22.7%）参与者死亡，其中107人死于心血管疾病。与血清25（OH）D最高四分位数（>26.5 ng/mL）（转换为nmol/L，乘以2.496）的参与者相比，血清25（OH）D最低四分位数（<10.5 ng/mL）的参与者全因死亡的风险增加（危险比[HR] 2.11，95%置信区间[C.I.] 1.22- 3.64，P = 0.007）和心血管疾病死亡率（H.R. 2.64，95% CI。1.14- 4.79，P = 0.02），在多变量考克斯比例风险模型，调整了年龄，性别，教育，季节，体力活动，和其他潜在的混杂因素。低血清25（OH）D的社区老年人全因死亡率和心血管疾病死亡率的风险较高。
Vitamin D deficiency is associated with cardiovascular disease, osteoporosis, poor muscle strength, falls, fractures, and mortality. Although older adults are at a high risk of vitamin D deficiency, the relationship of serum 25(OH)D with all-cause and cardiovascular disease mortality has not been well characterized in the elderly. We hypothesized that low serum 25(OH)D predicted mortality in older adults. Serum 25(OH)D and all-cause and cardiovascular disease mortality were examined in 1006 adults, ≥65 years, who participated in the InCHIANTI study, a population-based, prospective cohort study of aging in Tuscany, Italy. Serum 25(OH)D was measured at enrollment in 1998-1999, and participants were followed for mortality. During 6.5 years of follow-up, 228 (22.7%) participants died, of whom 107 died from cardiovascular disease. Compared with participants in the highest quartile of serum 25(OH)D (>26.5 ng/mL)(to convert to nmol/L, multiply by 2.496), those in the lowest quartile (<10.5 ng/mL) had increased risk of all-cause mortality (Hazards Ratio [H.R.] 2.11, 95% Confidence Interval [C.I.] 1.22 – 3.64, P = 0.007) and cardiovascular disease mortality (H.R. 2.64, 95% C.I. 1.14 – 4.79, P = 0.02), in multivariate Cox proportional hazards models that adjusted for age, sex, education, season, physical activity, and other potential confounders. Older community-dwelling adults with low serum 25(OH)D are at higher risk of all-cause and cardiovascular disease mortality.
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影响因子：
120.7
作者：
GLOTH, FM;GUNDBERG, CM;TOBIN, JD
通讯作者：
TOBIN, JD
DOI：
10.1111/j.1532-5415.2000.tb03873.x
发表时间：
2000-12-01
影响因子：
6.3
作者：
Ferrucci, L;Bandinelli, S;Guralnik, JM
通讯作者：
Guralnik, JM
DOI：
10.2215/cjn.00900208
发表时间：
2008-11-01
影响因子：
9.8
作者：
Andrade, Jason;Er, Lee;Levin, Adeera
通讯作者：
Levin, Adeera
影响因子：
5.3
作者：
Cardus, Anna;Panizo, Sara;Valdivielso, Jose M.
通讯作者：
Valdivielso, Jose M.
影响因子：
--
作者：
Melamed, Michal L.;Michos, Erin D.;Post, Wendy;Astor, Brad
通讯作者：
Astor, Brad