Quercetin-induced cardioprotection against doxorubicin cytotoxicity.
Quercetin-induced cardioprotection against doxorubicin cytotoxicity.
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DOI：
10.1186/1423-0127-20-95
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发表时间：
2013-12-20
影响因子：
11
通讯作者：
Chou HC
中科院分区：
文献类型：
--
作者：
Chen JY;Hu RY;Chou HC
Cancer has continually been the leading cause of death worldwide for decades. Thus, scientists have actively devoted themselves to studying cancer therapeutics. Doxorubicin is an efficient drug used in cancer therapy, but also produces reactive oxygen species (ROS) that induce severe cytotoxicity against heart cells. Quercetin, a plant-derived flavonoid, has been proven to contain potent antioxidant and anti-inflammatory properties. Thus, this in vitro study investigated whether quercetin can decrease doxorubicin-induced cytotoxicity and promote cell repair systems in cardiomyocyte H9C2 cells. Proteomic analysis and a cell biology assay were performed to investigate the quercetin-induced responses. Our data demonstrated that quercetin treatment protects the cardiomyocytes in a doxorubicin-induced heart damage model. Quercetin significantly facilitated cell survival by inhibiting cell apoptosis and maintaining cell morphology by rearranging the cytoskeleton. Additionally, 2D-DIGE combined with MALDI-TOF MS analysis indicated that quercetin might stimulate cardiomyocytes to repair damage after treating doxorubicin by modulating metabolic activation, protein folding and cytoskeleton rearrangement. Based on a review of the literature, this study is the first to report detailed protective mechanisms for the action of quercetin against doxorubicin-induced cardiomyocyte toxicity based on in-depth cell biology and proteomic analysis.
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影响因子：
3.3
作者：
Chou, Hsiu-Chuan;Lu, Ying-Chieh;Chan, Hong-Lin
通讯作者：
Chan, Hong-Lin
影响因子：
3.2
作者：
Mokni, Meherzia;Hamlaoui-Guesmi, Sonia;Aouani, Ezzedine
通讯作者：
Aouani, Ezzedine
影响因子：
5.4
作者：
Kyaw, M;Yoshizumi, M;Tamaki, T
通讯作者：
Tamaki, T
影响因子：
4.3
作者：
Bongiovanni, G. A.;Soria, E. A.;Eynard, A. R.
通讯作者：
Eynard, A. R.
槲皮素、EGCG、儿茶素和甜菜碱对体外乙醇诱导的氧化应激的保护作用。
影响因子：
3.6
作者：
Oliva, Joan;Bardag-Gorce, Fawzia;Tillman, Brittany;French, Samuel W.
通讯作者：
French, Samuel W.