N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms.
N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms.
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DOI：
10.1111/jnc.12613
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发表时间：
2014-04
影响因子：
4.7
通讯作者：
Chiesa JJ
中科院分区：
文献类型：
--
作者：
Baidanoff FM;Plano SA;Doctorovich F;Suárez SA;Golombek DA;Chiesa JJ
Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employed a novel nitric oxide-donor, N-nitrosomelatonin, to enhance the photic synchronization of circadian rhythms in hamsters. The intraperitoneal administration of this drug before a sub-saturating light pulse at circadian time 18 generated a two-fold increase of locomotor rhythm phase-advances, having no effect over saturating light pulses. This potentiation was also obtained even when inhibiting suprachiasmatic nitric oxide synthase activity. However, N-nitrosomelatonin had no effect on light-induced phase delays at circadian time 14. The photic-enhancing effects were correlated with an increased suprachiasmatic immunoreactivity of cFOS and PER1. Moreover, in vivo nitric oxide release by N-nitrosomelatonin was verified by measuring nitrate and nitrite levels in suprachiasmatic nuclei homogenates. The compound also accelerated resynchronization to an abrupt 6-h advance in the light:dark cycle (but not resynchronization to a 6-hour delay). Here we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances.
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DOI：
10.1016/j.niox.2009.07.002
发表时间：
2009-09
期刊：
Nitric oxide : biology and chemistry
影响因子：
--
作者：
Hall CN;Garthwaite J
通讯作者：
Garthwaite J
影响因子：
3.3
作者：
Edelstein, K;De La Iglesia, HO;Mrosovsky, N
通讯作者：
Mrosovsky, N
影响因子：
3.6
作者：
Aida, R;Moriya, T;Shibata, S
通讯作者：
Shibata, S
影响因子：
2.9
作者：
Dardente, H;Poirel, VJ;Masson-Pévet, M
通讯作者：
Masson-Pévet, M
影响因子：
64.8
作者：
Ding, JM;Buchanan, GF;Gillette, MU
通讯作者：
Gillette, MU