SARS-CoV-2 infections in infants in Haiti 2020-2021; evidence from a seroepidemiological cohort.
SARS-CoV-2 infections in infants in Haiti 2020-2021; evidence from a seroepidemiological cohort.
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海地2020-2021婴儿的SARS-COV-2感染；来自血清ePIDEMIologic Stole的证据。
DOI：
10.1371/journal.pone.0273482
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
关于中低收入国家幼儿中SARS-CoV-2感染频率的数据很少，现有研究偏向于报告感染率和血清转化率较低的高收入国家。在2019年2月至2021年3月期间，从257名年龄小于30个月的儿童中获得了388份干血斑（DBS）样本，作为海地孕妇及其婴儿前瞻性观察性队列研究的一部分;纵向样本可用于107名儿童。在随后的回顾性分析中，通过ELISA检测DBS样本中靶向SARS-CoV-2 S1蛋白受体结合域的抗体。在研究过程中，16.7%的婴儿血清反应呈阳性。所有血清阳性样本均于2020年3月19日（海地首次报告COVID-19病例的日期）之后采集，2020年8月测量的危害最高。采样日期是唯一与血清转换风险相关的协变量。我们的数据提供了一个估计的SARS-CoV-2感染率非常年幼的儿童没有事先接触SARS-CoV-2在最初的大流行波在海地，并表明，这些儿童安装一个可检测的血清学反应，这是独立于患者的年龄。
Few data are available on frequency of SARS-CoV-2 infection among very young children in low- to middle-income countries (LMIC), with the studies that are available biased towards higher income countries with low reported infection and seroconversion rates. Between February 2019 and March 2021, 388 dried blood spot (DBS) samples were obtained from 257 children less than 30 months of age as part of a prospective observational cohort study of pregnant women and their infants in Haiti; longitudinal samples were available for 107 children. In a subsequent retrospective analysis, DBS samples were tested by ELISA for antibody targeting the receptor binding domain of the SARS-CoV-2 S1 protein. Over the course of the study, 16·7% of the infants became seropositive. All seropositive samples were collected after March 19, 2020 (the date of the first reported COVID-19 case in Haiti) with the highest hazards measured in August 2020. Sampling date was the only covariate associated with the hazard of seroconversion. Our data provide an estimate of SARS-CoV-2 infection rates among very young children without prior SARS-CoV-2 exposure during the initial pandemic waves in Haiti, and demonstrate that these children mount a detectable serological response which is independent of patient age.
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与阳性SARS-COV-2测试相关的因素会导致门诊医疗机构和急诊科的儿童和青少年<18岁 - 密西西比州，2020年9月至11月。
DOI：
10.15585/mmwr.mm6950e3
发表时间：
2020-12-18
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Hobbs CV;Martin LM;Kim SS;Kirmse BM;Haynie L;McGraw S;Byers P;Taylor KG;Patel MM;Flannery B;CDC COVID-19 Response Team
通讯作者：
CDC COVID-19 Response Team
影响因子：
26.1
作者：
Tönshoff B;Müller B;Elling R;Renk H;Meissner P;Hengel H;Garbade SF;Kieser M;Jeltsch K;Grulich-Henn J;Euler J;Stich M;Chobanyan-Jürgens K;Zernickel M;Janda A;Wölfle L;Stamminger T;Iftner T;Ganzenmueller T;Schmitt C;Görne T;Laketa V;Olberg S;Plaszczyca A;Cortese M;Bartenschlager R;Pape C;Remme R;Huzly D;Panning M;Weigang S;Giese S;Ciminski K;Ankerhold J;Kochs G;Schwemmle M;Handgretinger R;Niemeyer CM;Engel C;Kern WV;Hoffmann GF;Franz AR;Henneke P;Debatin KM;Kräusslich HG
通讯作者：
Kräusslich HG
影响因子：
2.2
作者：
Roy, Vicky;Fischinger, Stephanie;Alter, Galit
通讯作者：
Alter, Galit
影响因子：
3.7
作者：
Cento V;Alteri C;Merli M;Di Ruscio F;Tartaglione L;Rossotti R;Travi G;Vecchi M;Raimondi A;Nava A;Colagrossi L;Fumagalli R;Ughi N;Epis OM;Fanti D;Beretta A;Galbiati F;Scaglione F;Vismara C;Puoti M;Campisi D;Perno CF
通讯作者：
Perno CF
影响因子：
3.6
作者：
Bahar, Burak;Simpson, Joelle N.;Delaney, Meghan
通讯作者：
Delaney, Meghan