Periostin expression and its prognostic value for colorectal cancer.
Periostin expression and its prognostic value for colorectal cancer.
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DOI：
10.3390/ijms160612108
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发表时间：
2015-05-27
影响因子：
5.6
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Li Z;Zhang X;Yang Y;Yang S;Dong Z;Du L;Wang L;Wang C
整合素在细胞生长、侵袭和转移过程中起重要作用，是恶性肿瘤中常见的生物学行为。骨膜蛋白（periostin，POSTs）基因编码整合素的配体，整合素是有助于细胞外基质和整合素之间形成结构连接的关键粘着斑蛋白之一。POR 4基因的高表达水平与许多人类恶性肿瘤相关。我们采用免疫组化方法检测了115例结直肠癌组织中POR 4蛋白的表达。胞浆免疫组化染色显示大肠癌中POR 4蛋白表达。大肠癌组织中POR 4蛋白的阳性表达率（59.13%，68/115）显著高于癌旁正常结肠黏膜（0.47%，11/109）。大肠癌组织中POX 4过表达与肿瘤大小、分化程度、淋巴结转移、浸润深度、临床分期及5年生存率呈正相关。进一步分析显示，晚期结直肠癌和高表达水平的患者的生存率低于早期结直肠癌和低表达水平的患者。总的来说，我们的研究结果表明，POL 4在结直肠癌的进展中发挥了重要作用。
Integrin is important for cell growth, invasion and metastasis, which are frequently observed in malignant tumors. The periostin (POSTN) gene encodes the ligand for integrin, one of the key focal adhesion proteins contributing to the formation of a structural link between the extracellular matrix and integrins. High expression levels of the POSTN gene are correlated with numerous human malignancies. We examined POSTN protein in colorectal cancer specimens from 115 patients by strictly following up using immunohistochemistry. Cytoplasm immunohistochemical staining showed POSTN protein expression in colorectal cancers. The positive expression rate of POSTN protein (59.13%, 68/115) in colorectal cancers was significantly higher than that in adjacent normal colon mucosa (0.47%, 11/109). POSTN over-expression in colorectal cancers was positively correlated with tumor size, differentiation, lymph node metastasis, serosal invasion, clinical stage and five-year survival rates. Further analysis showed that patients with advanced stage colorectal cancer and high POSTN expression levels had lower survival rates than those with early stage colorectal cancer and low POSTN expression levels. Overall, our results showed that POSTN played an important role in the progression of colorectal cancers.
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骨膜素经常过表达，并增强口腔癌的侵袭和血管生成。
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