Association of Allostatic Load and All Cancer Risk in the SWAN Cohort.
Association of Allostatic Load and All Cancer Risk in the SWAN Cohort.
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DOI：
10.3390/cancers14133044
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发表时间：
2022-06-21
期刊：
影响因子：
5.2
通讯作者：
Zhao, Hua
中科院分区：
文献类型：
--
作者：
Shen, Jie;Fuemmeler, Bernard F.;Guan, Yufan;Zhao, Hua
慢性压力与许多慢性疾病的风险增加有关。然而，它对癌症风险的贡献仍不清楚。在这项研究中，我们在全国妇女健康研究（SWAN）中分析了非稳态负荷（AL）（慢性压力的生物标志物）与癌症风险之间的关系。我们发现，AL水平最高的女性患癌症的风险增加了64%。这种关联与人口统计学、健康行为和社会经济因素无关。总之，我们提供的证据表明，慢性压力可能会增加患癌症的风险。 人们认为长期压力升高会增加患癌症的风险，尽管迄今为止的结果并不一致。在这项研究中，我们评估了3015名参加全国妇女健康研究（SWAN）的妇女的非稳态负荷（AL）（慢性压力的生物学指标）与总体癌症风险之间的关系。根据AL的分布，将研究人群分为4组，从最低（第1类）到最高AL组（第4类）。在基线时，非洲裔美国人和西班牙裔妇女比白色妇女更可能属于较高的AL类别（p < 0.001）。此外，经常吸烟、经常饮酒、没有休闲体育活动和睡眠不安的女性也比其相对同行更有可能处于较高的AL类别（p < 0.001）。我们还观察到，没有医疗保险的低收入类别的妇女更有可能属于较高的AL类别（p < 0.001）。研究发现，第四类AL（最高AL组）的女性患癌症的风险增加了1.64倍（风险比（HR）：1.64，95%置信区间（CI）：1.04，2.59）。在调整人口统计学、健康行为和社会经济因素后，风险相关性进一步加强，HR为2.08。在对AL评分的个体生物标志物的进一步分析中，我们发现甘油三酯和CRP水平较高与癌症风险增加相关，突出了代谢功能障碍和炎症在癌症发展病因中的作用。总之，我们报告AL较高与癌症风险增加有关。
Chronic stress has been linked to increased risks for many chronic diseases. However, its contribution to cancer risk is still unclear. In this study, we analyzed the association between allostatic load (AL), a biomarker of chronic stress, and cancer risk, in the Study of Women’s Health Across the Nation (SWAN). We found that women with the highest levels of AL had a 64% increased risk of overall cancer. And the association was independent of demographics, healthy behaviors, and socioeconomic factors. In summary, we provide evidence that chronic stress may increase the risk of cancer. Elevated chronic stress is thought to increase cancer risk, though the results so far have been inconsistent. In this study, we assessed the relationship between allostatic load (AL), a biological indicator of chronic stress, and overall cancer risk in 3015 women who participated in the Study of Women’s Health Across the Nation (SWAN). Based on the distribution of AL, the study population was categorized into four groups, from the lowest (1st category) to the highest AL group (4th category). At baseline, African American and Hispanic women were more likely to be in the higher AL categories than White women (p < 0.001). In addition, women who smoked regularly, drank alcohol regularly, had no leisure physical activity, and had restless sleep were also more likely to be in the higher AL categories than their relative counterparts (p < 0.001). We also observed that women in the lower-income category with no health insurance were more likely to be in the higher AL category (p < 0.001). The study then found that women in the 4th category of AL (the highest AL group) had a 1.64-fold increased risk of overall cancer (Hazard ratio (HR): 1.64, 95% confidence interval (CI): 1.04, 2.59). The risk association was further strengthened after adjusting demographics, healthy behaviors, and socioeconomic factors with an HR of 2.08. In further analysis of individual biomarkers of AL score, we found that higher levels of triglyceride and CRP were associated with increased risk of cancer, highlighting the role of metabolic dysfunction and inflammation in the etiology of cancer development. In summary, we report that higher AL is associated with increased cancer risk.
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影响因子：
1.9
作者：
Gay, Jennifer L.;Salinas, Jennifer J.;Buchner, David M.;Mirza, Shaper;Kohl, Harold W., III;Fisher-Hoch, Susan P.;McCormick, Joseph B.
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